Minimal In Vivo Efficacy of Iminosugars in a Lethal Ebola Virus Guinea Pig Model

The antiviral properties of iminosugars have been reported previously in vitro and in small animal models against Ebola virus (EBOV); however, their effects have not been tested in larger animal models such as guinea pigs. We tested the iminosugars N-butyl-deoxynojirimycin (NB-DNJ) and N-(9-methoxyn...

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Detalles Bibliográficos
Autores principales: Miller, Joanna L., Spiro, Simon G., Dowall, Stuart D., Taylor, Irene, Rule, Antony, Alonzi, Dominic S., Sayce, Andrew C., Wright, Edward, Bentley, Emma M., Thom, Ruth, Hall, Graham, Dwek, Raymond A., Hewson, Roger, Zitzmann, Nicole
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5120828/
https://www.ncbi.nlm.nih.gov/pubmed/27880800
http://dx.doi.org/10.1371/journal.pone.0167018

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