Cyclin Kinase-independent role of p21(CDKN1A) in the promotion of nascent DNA elongation in unstressed cells

The levels of the cyclin-dependent kinase (CDK) inhibitor p21 are low in S phase and insufficient to inhibit CDKs. We show here that endogenous p21, instead of being residual, it is functional and necessary to preserve the genomic stability of unstressed cells. p21depletion slows down nascent DNA el...

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Detalles Bibliográficos
Autores principales: Mansilla, Sabrina F, Bertolin, Agustina P, Bergoglio, Valérie, Pillaire, Marie-Jeanne, González Besteiro, Marina A, Luzzani, Carlos, Miriuka, Santiago G, Cazaux, Christophe, Hoffmann, Jean-Sébastien, Gottifredi, Vanesa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2016
Materias:
Cancer Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5120883/
https://www.ncbi.nlm.nih.gov/pubmed/27740454
http://dx.doi.org/10.7554/eLife.18020

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5120883/
https://www.ncbi.nlm.nih.gov/pubmed/27740454
http://dx.doi.org/10.7554/eLife.18020

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