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A nomogram for predicting the likelihood of lymph node metastasis in early gastric signet ring cell carcinoma: A single center retrospective analysis with external validation

Treatment algorithm has not been established for early gastric cancer with signet ring cell carcinoma (SRC), which has a reported low rate of lymph node metastasis (LNM) similar to differentiated cancer. A cohort of 256 patients with early gastric SRC at our center between January 2002 and December...

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Autores principales: Guo, Chun Guang, Chen, Yan Jia, Ren, Hu, Zhou, Hong, Shi, Ju Fang, Yuan, Xing Hua, Zhao, Ping, Zhao, Dong Bing, Wang, Gui Qi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5120931/
https://www.ncbi.nlm.nih.gov/pubmed/27861374
http://dx.doi.org/10.1097/MD.0000000000005393
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author Guo, Chun Guang
Chen, Yan Jia
Ren, Hu
Zhou, Hong
Shi, Ju Fang
Yuan, Xing Hua
Zhao, Ping
Zhao, Dong Bing
Wang, Gui Qi
author_facet Guo, Chun Guang
Chen, Yan Jia
Ren, Hu
Zhou, Hong
Shi, Ju Fang
Yuan, Xing Hua
Zhao, Ping
Zhao, Dong Bing
Wang, Gui Qi
author_sort Guo, Chun Guang
collection PubMed
description Treatment algorithm has not been established for early gastric cancer with signet ring cell carcinoma (SRC), which has a reported low rate of lymph node metastasis (LNM) similar to differentiated cancer. A cohort of 256 patients with early gastric SRC at our center between January 2002 and December 2015 were retrospectively reviewed. Multivariate logistic regression analysis was used to determine the independent factors of LNM. A nomogram for predicting LNM was constructed and internally validated. Additional external validation was performed using the database from Cancer Institute Ariake Hospital in Tokyo (n = 1273). Clinical performance of the model was assessed by decision analysis of curve. The overall LNM incidence was 12.9% (33/256). The multivariate logistic model identified sex, tumor size, and LVI as covariates associated with LNM. Subsequently, a nomogram consisted of sex, tumor size, and depth of invasion was established. The model showed qualified discrimination ability both in internal validation (area under curve, 0.801; 95% confidence interval [CI], 0.729–0.873) and in external dataset (area under curve, 0.707; 95% CI, 0.657–0.758). Based on the nomogram, treatment algorithm for early gastric SRC was proposed to assist clinicians in making better decisions. We developed a nomogram predicting risk of LNM for early gastric SRC, which should be helpful for patient counseling and surgical decision-making.
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spelling pubmed-51209312016-11-28 A nomogram for predicting the likelihood of lymph node metastasis in early gastric signet ring cell carcinoma: A single center retrospective analysis with external validation Guo, Chun Guang Chen, Yan Jia Ren, Hu Zhou, Hong Shi, Ju Fang Yuan, Xing Hua Zhao, Ping Zhao, Dong Bing Wang, Gui Qi Medicine (Baltimore) 5700 Treatment algorithm has not been established for early gastric cancer with signet ring cell carcinoma (SRC), which has a reported low rate of lymph node metastasis (LNM) similar to differentiated cancer. A cohort of 256 patients with early gastric SRC at our center between January 2002 and December 2015 were retrospectively reviewed. Multivariate logistic regression analysis was used to determine the independent factors of LNM. A nomogram for predicting LNM was constructed and internally validated. Additional external validation was performed using the database from Cancer Institute Ariake Hospital in Tokyo (n = 1273). Clinical performance of the model was assessed by decision analysis of curve. The overall LNM incidence was 12.9% (33/256). The multivariate logistic model identified sex, tumor size, and LVI as covariates associated with LNM. Subsequently, a nomogram consisted of sex, tumor size, and depth of invasion was established. The model showed qualified discrimination ability both in internal validation (area under curve, 0.801; 95% confidence interval [CI], 0.729–0.873) and in external dataset (area under curve, 0.707; 95% CI, 0.657–0.758). Based on the nomogram, treatment algorithm for early gastric SRC was proposed to assist clinicians in making better decisions. We developed a nomogram predicting risk of LNM for early gastric SRC, which should be helpful for patient counseling and surgical decision-making. Wolters Kluwer Health 2016-11-18 /pmc/articles/PMC5120931/ /pubmed/27861374 http://dx.doi.org/10.1097/MD.0000000000005393 Text en Copyright © 2016 the Author(s). Published by Wolters Kluwer Health, Inc. All rights reserved. http://creativecommons.org/licenses/by/4.0 This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0
spellingShingle 5700
Guo, Chun Guang
Chen, Yan Jia
Ren, Hu
Zhou, Hong
Shi, Ju Fang
Yuan, Xing Hua
Zhao, Ping
Zhao, Dong Bing
Wang, Gui Qi
A nomogram for predicting the likelihood of lymph node metastasis in early gastric signet ring cell carcinoma: A single center retrospective analysis with external validation
title A nomogram for predicting the likelihood of lymph node metastasis in early gastric signet ring cell carcinoma: A single center retrospective analysis with external validation
title_full A nomogram for predicting the likelihood of lymph node metastasis in early gastric signet ring cell carcinoma: A single center retrospective analysis with external validation
title_fullStr A nomogram for predicting the likelihood of lymph node metastasis in early gastric signet ring cell carcinoma: A single center retrospective analysis with external validation
title_full_unstemmed A nomogram for predicting the likelihood of lymph node metastasis in early gastric signet ring cell carcinoma: A single center retrospective analysis with external validation
title_short A nomogram for predicting the likelihood of lymph node metastasis in early gastric signet ring cell carcinoma: A single center retrospective analysis with external validation
title_sort nomogram for predicting the likelihood of lymph node metastasis in early gastric signet ring cell carcinoma: a single center retrospective analysis with external validation
topic 5700
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5120931/
https://www.ncbi.nlm.nih.gov/pubmed/27861374
http://dx.doi.org/10.1097/MD.0000000000005393
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