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Changes in weight and weight distribution across the lifespan among HIV-infected and -uninfected men and women

Examine body composition changes across the lifespan of HIV-infected compared to uninfected adults. Longitudinal study of antiretroviral therapy (ART)-treated HIV-infected and uninfected participants from the Multicenter AIDS Cohort Study and Women's Interagency HIV Study. Body mass index (BMI)...

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Autores principales: Erlandson, Kristine M., Zhang, Long, Lake, Jordan E., Schrack, Jennifer, Althoff, Keri, Sharma, Anjali, Tien, Phyllis C., Margolick, Joseph B., Jacobson, Lisa P., Brown, Todd T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5120935/
https://www.ncbi.nlm.nih.gov/pubmed/27861378
http://dx.doi.org/10.1097/MD.0000000000005399
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author Erlandson, Kristine M.
Zhang, Long
Lake, Jordan E.
Schrack, Jennifer
Althoff, Keri
Sharma, Anjali
Tien, Phyllis C.
Margolick, Joseph B.
Jacobson, Lisa P.
Brown, Todd T.
author_facet Erlandson, Kristine M.
Zhang, Long
Lake, Jordan E.
Schrack, Jennifer
Althoff, Keri
Sharma, Anjali
Tien, Phyllis C.
Margolick, Joseph B.
Jacobson, Lisa P.
Brown, Todd T.
author_sort Erlandson, Kristine M.
collection PubMed
description Examine body composition changes across the lifespan of HIV-infected compared to uninfected adults. Longitudinal study of antiretroviral therapy (ART)-treated HIV-infected and uninfected participants from the Multicenter AIDS Cohort Study and Women's Interagency HIV Study. Body mass index (BMI), waist (WC), hip circumference (HC), and waist-to-height ratio (WHtR) measured at semiannual visits from 1999 to 2014. The age effect on outcomes over time was investigated using multivariate, piecewise, linear mixed-effect regression models adjusted for demographics, substance use, and comorbidities. Person-visits from 2363 men (1059 HIV-infected/1304 HIV-uninfected) and 2200 women (1455 HIV-infected/745 HIV-uninfected), median ages 45 [IQR 39,51] and 40 [32,46], respectively, were included. BMI gains were slower among HIV-infected participants of 40 years or less (P < 0.001), similar between HIV-infected and uninfected persons 40 to 60 years of age, and plateaued after age 60 in both groups. WC and WHtR increased across the age spectrum (P < 0.001) regardless of HIV serostatus, with significantly greater gains in HIV-infected men more than 60. Black race and Hispanic ethnicity were associated with greater BMI and WC. Lower BMI, WC, hip circumference, and WHtR were associated with hepatitis C infection among women only, and with substance use among all participants, and with lower CD4(+) cell count and shorter ART duration among HIV-infected participants. Slower BMI gain among younger HIV-infected adults may be partly explained by substance use and hepatitis C infection, and suggests that lower BMI does not represent improved health. Further analysis of muscle and fat abundance and quality will advance understanding of metabolic risk over the lifespan, a key to reducing morbidity in an aging population.
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spelling pubmed-51209352016-11-28 Changes in weight and weight distribution across the lifespan among HIV-infected and -uninfected men and women Erlandson, Kristine M. Zhang, Long Lake, Jordan E. Schrack, Jennifer Althoff, Keri Sharma, Anjali Tien, Phyllis C. Margolick, Joseph B. Jacobson, Lisa P. Brown, Todd T. Medicine (Baltimore) 4850 Examine body composition changes across the lifespan of HIV-infected compared to uninfected adults. Longitudinal study of antiretroviral therapy (ART)-treated HIV-infected and uninfected participants from the Multicenter AIDS Cohort Study and Women's Interagency HIV Study. Body mass index (BMI), waist (WC), hip circumference (HC), and waist-to-height ratio (WHtR) measured at semiannual visits from 1999 to 2014. The age effect on outcomes over time was investigated using multivariate, piecewise, linear mixed-effect regression models adjusted for demographics, substance use, and comorbidities. Person-visits from 2363 men (1059 HIV-infected/1304 HIV-uninfected) and 2200 women (1455 HIV-infected/745 HIV-uninfected), median ages 45 [IQR 39,51] and 40 [32,46], respectively, were included. BMI gains were slower among HIV-infected participants of 40 years or less (P < 0.001), similar between HIV-infected and uninfected persons 40 to 60 years of age, and plateaued after age 60 in both groups. WC and WHtR increased across the age spectrum (P < 0.001) regardless of HIV serostatus, with significantly greater gains in HIV-infected men more than 60. Black race and Hispanic ethnicity were associated with greater BMI and WC. Lower BMI, WC, hip circumference, and WHtR were associated with hepatitis C infection among women only, and with substance use among all participants, and with lower CD4(+) cell count and shorter ART duration among HIV-infected participants. Slower BMI gain among younger HIV-infected adults may be partly explained by substance use and hepatitis C infection, and suggests that lower BMI does not represent improved health. Further analysis of muscle and fat abundance and quality will advance understanding of metabolic risk over the lifespan, a key to reducing morbidity in an aging population. Wolters Kluwer Health 2016-11-18 /pmc/articles/PMC5120935/ /pubmed/27861378 http://dx.doi.org/10.1097/MD.0000000000005399 Text en Copyright © 2016 the Author(s). Published by Wolters Kluwer Health, Inc. All rights reserved. http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. http://creativecommons.org/licenses/by-nc-sa/4.0
spellingShingle 4850
Erlandson, Kristine M.
Zhang, Long
Lake, Jordan E.
Schrack, Jennifer
Althoff, Keri
Sharma, Anjali
Tien, Phyllis C.
Margolick, Joseph B.
Jacobson, Lisa P.
Brown, Todd T.
Changes in weight and weight distribution across the lifespan among HIV-infected and -uninfected men and women
title Changes in weight and weight distribution across the lifespan among HIV-infected and -uninfected men and women
title_full Changes in weight and weight distribution across the lifespan among HIV-infected and -uninfected men and women
title_fullStr Changes in weight and weight distribution across the lifespan among HIV-infected and -uninfected men and women
title_full_unstemmed Changes in weight and weight distribution across the lifespan among HIV-infected and -uninfected men and women
title_short Changes in weight and weight distribution across the lifespan among HIV-infected and -uninfected men and women
title_sort changes in weight and weight distribution across the lifespan among hiv-infected and -uninfected men and women
topic 4850
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5120935/
https://www.ncbi.nlm.nih.gov/pubmed/27861378
http://dx.doi.org/10.1097/MD.0000000000005399
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