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Muscle-Type Nicotinic Receptor Modulation by 2,6-Dimethylaniline, a Molecule Resembling the Hydrophobic Moiety of Lidocaine

To identify the molecular determinants responsible for lidocaine blockade of muscle-type nAChRs, we have studied the effects on this receptor of 2,6-dimethylaniline (DMA), which resembles lidocaine’s hydrophobic moiety. Torpedo marmorata nAChRs were microtransplanted to Xenopus oocytes and currents...

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Detalles Bibliográficos
Autores principales:	Alberola-Die, Armando, Fernández-Ballester, Gregorio, González-Ros, José M., Ivorra, Isabel, Morales, Andrés
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2016
Materias:	Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5121239/ https://www.ncbi.nlm.nih.gov/pubmed/27932949 http://dx.doi.org/10.3389/fnmol.2016.00127

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