Disease-associated marked hyperalphalipoproteinemia

Marked hyperalphalipoproteinemia (HAL) is a heterogeneous syndrome. To clarify the pathophysiological significance of HAL, we compared clinical profiles between marked HAL subjects with and without cholesteryl ester transfer protein (CETP) deficiency. CETP deficiency was associated with cardiovascul...

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Detalles Bibliográficos
Autores principales: Hirano, Ken-ichi, Nagasaka, Hironori, Kobayashi, Kazuhiro, Yamaguchi, Satoshi, Suzuki, Akira, Toda, Tatsushi, Doyu, Manabu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2014
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5121302/
https://www.ncbi.nlm.nih.gov/pubmed/27896098
http://dx.doi.org/10.1016/j.ymgmr.2014.06.001
Descripción
Sumario:Marked hyperalphalipoproteinemia (HAL) is a heterogeneous syndrome. To clarify the pathophysiological significance of HAL, we compared clinical profiles between marked HAL subjects with and without cholesteryl ester transfer protein (CETP) deficiency. CETP deficiency was associated with cardiovascular diseases and strokes in the HAL population, particularly in female. HAL women without CETP deficiency tended to have higher prevalence with cancer history. HAL may not always be a longevity marker, but be sometimes accompanied with pathological conditions.

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