Disease-associated marked hyperalphalipoproteinemia

Marked hyperalphalipoproteinemia (HAL) is a heterogeneous syndrome. To clarify the pathophysiological significance of HAL, we compared clinical profiles between marked HAL subjects with and without cholesteryl ester transfer protein (CETP) deficiency. CETP deficiency was associated with cardiovascul...

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Autores principales: Hirano, Ken-ichi, Nagasaka, Hironori, Kobayashi, Kazuhiro, Yamaguchi, Satoshi, Suzuki, Akira, Toda, Tatsushi, Doyu, Manabu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2014
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5121302/
https://www.ncbi.nlm.nih.gov/pubmed/27896098
http://dx.doi.org/10.1016/j.ymgmr.2014.06.001
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author Hirano, Ken-ichi
Nagasaka, Hironori
Kobayashi, Kazuhiro
Yamaguchi, Satoshi
Suzuki, Akira
Toda, Tatsushi
Doyu, Manabu
author_facet Hirano, Ken-ichi
Nagasaka, Hironori
Kobayashi, Kazuhiro
Yamaguchi, Satoshi
Suzuki, Akira
Toda, Tatsushi
Doyu, Manabu
author_sort Hirano, Ken-ichi
collection PubMed
description Marked hyperalphalipoproteinemia (HAL) is a heterogeneous syndrome. To clarify the pathophysiological significance of HAL, we compared clinical profiles between marked HAL subjects with and without cholesteryl ester transfer protein (CETP) deficiency. CETP deficiency was associated with cardiovascular diseases and strokes in the HAL population, particularly in female. HAL women without CETP deficiency tended to have higher prevalence with cancer history. HAL may not always be a longevity marker, but be sometimes accompanied with pathological conditions.
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spelling pubmed-51213022016-11-28 Disease-associated marked hyperalphalipoproteinemia Hirano, Ken-ichi Nagasaka, Hironori Kobayashi, Kazuhiro Yamaguchi, Satoshi Suzuki, Akira Toda, Tatsushi Doyu, Manabu Mol Genet Metab Rep Short Communication Marked hyperalphalipoproteinemia (HAL) is a heterogeneous syndrome. To clarify the pathophysiological significance of HAL, we compared clinical profiles between marked HAL subjects with and without cholesteryl ester transfer protein (CETP) deficiency. CETP deficiency was associated with cardiovascular diseases and strokes in the HAL population, particularly in female. HAL women without CETP deficiency tended to have higher prevalence with cancer history. HAL may not always be a longevity marker, but be sometimes accompanied with pathological conditions. Elsevier 2014-06-30 /pmc/articles/PMC5121302/ /pubmed/27896098 http://dx.doi.org/10.1016/j.ymgmr.2014.06.001 Text en © 2014 The Authors http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/3.0/).
spellingShingle Short Communication
Hirano, Ken-ichi
Nagasaka, Hironori
Kobayashi, Kazuhiro
Yamaguchi, Satoshi
Suzuki, Akira
Toda, Tatsushi
Doyu, Manabu
Disease-associated marked hyperalphalipoproteinemia
title Disease-associated marked hyperalphalipoproteinemia
title_full Disease-associated marked hyperalphalipoproteinemia
title_fullStr Disease-associated marked hyperalphalipoproteinemia
title_full_unstemmed Disease-associated marked hyperalphalipoproteinemia
title_short Disease-associated marked hyperalphalipoproteinemia
title_sort disease-associated marked hyperalphalipoproteinemia
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5121302/
https://www.ncbi.nlm.nih.gov/pubmed/27896098
http://dx.doi.org/10.1016/j.ymgmr.2014.06.001
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