Cerebral vascular amyloid seeds drive amyloid β-protein fibril assembly with a distinct anti-parallel structure

Cerebrovascular accumulation of amyloid β-protein (Aβ), a condition known as cerebral amyloid angiopathy (CAA), is a common pathological feature of patients with Alzheimer's disease. Familial Aβ mutations, such as Dutch-E22Q and Iowa-D23N, can cause severe cerebrovascular accumulation of amyloi...

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Detalles Bibliográficos
Autores principales: Xu, Feng, Fu, Ziao, Dass, Sharmila, Kotarba, AnnMarie E., Davis, Judianne, Smith, Steven O., Van Nostrand, William E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5121328/
https://www.ncbi.nlm.nih.gov/pubmed/27869115
http://dx.doi.org/10.1038/ncomms13527

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