Reprogramming mouse fibroblasts into engraftable myeloerythroid and lymphoid progenitors

Recent efforts have attempted to convert non-blood cells into hematopoietic stem cells (HSCs) with the goal of generating blood lineages de novo. Here we show that hematopoietic transcription factors Scl, Lmo2, Runx1 and Bmi1 can convert a developmentally distant lineage (fibroblasts) into ‘induced...

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Detalles Bibliográficos
Autores principales: Cheng, Hui, Ang, Heather Yin-Kuan, A. EL Farran, Chadi, Li, Pin, Fang, Hai Tong, Liu, Tong Ming, Kong, Say Li, Chin, Michael Lingzi, Ling, Wei Yin, Lim, Edwin Kok Hao, Li, Hu, Huber, Tara, Loh, Kyle M., Loh, Yuin-Han, Lim, Bing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5121332/
https://www.ncbi.nlm.nih.gov/pubmed/27869129
http://dx.doi.org/10.1038/ncomms13396

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