Cargando…
A systems study reveals concurrent activation of AMPK and mTOR by amino acids
Amino acids (aa) are not only building blocks for proteins, but also signalling molecules, with the mammalian target of rapamycin complex 1 (mTORC1) acting as a key mediator. However, little is known about whether aa, independently of mTORC1, activate other kinases of the mTOR signalling network. To...
Autores principales: | Pezze, Piero Dalle, Ruf, Stefanie, Sonntag, Annika G., Langelaar-Makkinje, Miriam, Hall, Philip, Heberle, Alexander M., Navas, Patricia Razquin, van Eunen, Karen, Tölle, Regine C., Schwarz, Jennifer J., Wiese, Heike, Warscheid, Bettina, Deitersen, Jana, Stork, Björn, Fäßler, Erik, Schäuble, Sascha, Hahn, Udo, Horvatovich, Peter, Shanley, Daryl P., Thedieck, Kathrin |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2016
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5121333/ https://www.ncbi.nlm.nih.gov/pubmed/27869123 http://dx.doi.org/10.1038/ncomms13254 |
Ejemplares similares
-
The PI3K and MAPK/p38 pathways control stress granule assembly in a hierarchical manner
por: Heberle, Alexander Martin, et al.
Publicado: (2019) -
PLK1 (polo like kinase 1) inhibits MTOR complex 1 and promotes autophagy
por: Ruf, Stefanie, et al.
Publicado: (2017) -
Molecular mechanisms of mTOR regulation by stress
por: Heberle, Alexander Martin, et al.
Publicado: (2014) -
Dynamic Modelling of Pathways to Cellular Senescence Reveals Strategies for Targeted Interventions
por: Dalle Pezze, Piero, et al.
Publicado: (2014) -
Systems modelling ageing: from single senescent cells to simple multi-cellular models
por: Martinez Guimera, Alvaro, et al.
Publicado: (2017)