Direct identification of clinically relevant neoepitopes presented on native human melanoma tissue by mass spectrometry

Although mutations may represent attractive targets for immunotherapy, direct identification of mutated peptide ligands isolated from human leucocyte antigens (HLA) on the surface of native tumour tissue has so far not been successful. Using advanced mass spectrometry (MS) analysis, we survey the me...

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Detalles Bibliográficos
Autores principales: Bassani-Sternberg, Michal, Bräunlein, Eva, Klar, Richard, Engleitner, Thomas, Sinitcyn, Pavel, Audehm, Stefan, Straub, Melanie, Weber, Julia, Slotta-Huspenina, Julia, Specht, Katja, Martignoni, Marc E., Werner, Angelika, Hein, Rüdiger, H. Busch, Dirk, Peschel, Christian, Rad, Roland, Cox, Jürgen, Mann, Matthias, Krackhardt, Angela M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5121339/
https://www.ncbi.nlm.nih.gov/pubmed/27869121
http://dx.doi.org/10.1038/ncomms13404

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