The GCN5-CITED2-PKA signalling module controls hepatic glucose metabolism through a cAMP-induced substrate switch

Hepatic gluconeogenesis during fasting results from gluconeogenic gene activation via the glucagon–cAMP–protein kinase A (PKA) pathway, a process whose dysregulation underlies fasting hyperglycemia in diabetes. Such transcriptional activation requires epigenetic changes at promoters by mechanisms th...

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Detalles Bibliográficos
Autores principales: Sakai, Mashito, Tujimura-Hayakawa, Tomoko, Yagi, Takashi, Yano, Hiroyuki, Mitsushima, Masaru, Unoki-Kubota, Hiroyuki, Kaburagi, Yasushi, Inoue, Hiroshi, Kido, Yoshiaki, Kasuga, Masato, Matsumoto, Michihiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5121418/
https://www.ncbi.nlm.nih.gov/pubmed/27874008
http://dx.doi.org/10.1038/ncomms13147

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