Defective mitochondrial DNA homeostasis in the substantia nigra in Parkinson disease

Increased somatic mitochondrial DNA (mtDNA) mutagenesis causes premature aging in mice, and mtDNA damage accumulates in the human brain with aging and neurodegenerative disorders such as Parkinson disease (PD). Here, we study the complete spectrum of mtDNA changes, including deletions, copy-number v...

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Detalles Bibliográficos
Autores principales: Dölle, Christian, Flønes, Irene, Nido, Gonzalo S., Miletic, Hrvoje, Osuagwu, Nelson, Kristoffersen, Stine, Lilleng, Peer K., Larsen, Jan Petter, Tysnes, Ole-Bjørn, Haugarvoll, Kristoffer, Bindoff, Laurence A., Tzoulis, Charalampos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5121427/
https://www.ncbi.nlm.nih.gov/pubmed/27874000
http://dx.doi.org/10.1038/ncomms13548

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5121427/
https://www.ncbi.nlm.nih.gov/pubmed/27874000
http://dx.doi.org/10.1038/ncomms13548

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