Cargando…

Defective mitochondrial DNA homeostasis in the substantia nigra in Parkinson disease

Increased somatic mitochondrial DNA (mtDNA) mutagenesis causes premature aging in mice, and mtDNA damage accumulates in the human brain with aging and neurodegenerative disorders such as Parkinson disease (PD). Here, we study the complete spectrum of mtDNA changes, including deletions, copy-number v...

Descripción completa

Detalles Bibliográficos
Autores principales:	Dölle, Christian, Flønes, Irene, Nido, Gonzalo S., Miletic, Hrvoje, Osuagwu, Nelson, Kristoffersen, Stine, Lilleng, Peer K., Larsen, Jan Petter, Tysnes, Ole-Bjørn, Haugarvoll, Kristoffer, Bindoff, Laurence A., Tzoulis, Charalampos
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5121427/ https://www.ncbi.nlm.nih.gov/pubmed/27874000 http://dx.doi.org/10.1038/ncomms13548

Ejemplares similares

Early Forms of α-Synuclein Pathology Are Associated with Neuronal Complex I Deficiency in the Substantia Nigra of Individuals with Parkinson’s Disease
por: Flønes, Irene Hana, et al.
Publicado: (2022)

Meta-analysis of whole-exome sequencing data from two independent cohorts finds no evidence for rare variant enrichment in Parkinson disease associated loci
por: Gaare, Johannes Jernqvist, et al.
Publicado: (2020)

Genome-wide histone acetylation analysis reveals altered transcriptional regulation in the Parkinson’s disease brain
por: Toker, Lilah, et al.
Publicado: (2021)

Novel SLC19A3 Promoter Deletion and Allelic Silencing in Biotin-Thiamine-Responsive Basal Ganglia Encephalopathy
por: Flønes, Irene, et al.
Publicado: (2016)

Nicotinamide riboside supplementation is not associated with altered methylation homeostasis in Parkinson’s disease
por: Gaare, Johannes J., et al.
Publicado: (2023)

NSAID use is not associated with Parkinson’s disease incidence: A Norwegian Prescription Database study
por: Brakedal, Brage, et al.
Publicado: (2021)

Common gene expression signatures in Parkinson’s disease are driven by changes in cell composition
por: Nido, Gonzalo S., et al.
Publicado: (2020)

Ultra-deep whole genome bisulfite sequencing reveals a single methylation hotspot in human brain mitochondrial DNA
por: Guitton, Romain, et al.
Publicado: (2022)

Glitazone use associated with reduced risk of Parkinson's disease
por: Brakedal, Brage, et al.
Publicado: (2017)

Differential transcript usage in the Parkinson’s disease brain
por: Dick, Fiona, et al.
Publicado: (2020)

No evidence for rare TRAP1 mutations influencing the risk of idiopathic Parkinson’s disease
por: Gaare, Johannes J, et al.
Publicado: (2018)

Molecular Pathogenesis of Polymerase Gamma–Related Neurodegeneration
por: Tzoulis, Charalampos, et al.
Publicado: (2014)

Altered transcriptome-proteome coupling indicates aberrant proteostasis in Parkinson’s disease
por: Dick, Fiona, et al.
Publicado: (2023)

Rare genetic variation in mitochondrial pathways influences the risk for Parkinson's disease
por: Gaare, Johannes J., et al.
Publicado: (2018)

Soemmerring and the Substantia Nigra
por: Faull, R. L. M, et al.
Publicado: (1968)

Poly-ADP-ribose assisted protein localization resolves that DJ-1, but not LRRK2 or α-synuclein, is localized to the mitochondrial matrix
por: Osuagwu, Nelson, et al.
Publicado: (2019)

3,3′-Diaminobenzidine staining interferes with PCR-based DNA analysis
por: Dölle, Christian, et al.
Publicado: (2018)

A nationwide study of the incidence, prevalence and mortality of Parkinson’s disease in the Norwegian population
por: Brakedal, Brage, et al.
Publicado: (2022)

Mitochondrial Respiratory Chain Dysfunction—A Hallmark Pathology of Idiopathic Parkinson’s Disease?
por: Flønes, Irene H., et al.
Publicado: (2022)

The history of the research of iron in parkinsonian substantia nigra
por: Friedman, Andrzej, et al.
Publicado: (2012)

Isolated substantia nigra involvement in brainstem demyelination
por: Mahale, Rohan R., et al.
Publicado: (2015)

Nicotine impact on rat substantia nigra compacta
por: Elgayar, Sanaa A M, et al.
Publicado: (2021)

MRI characterisation of adult onset alpha-methylacyl-coA racemase deficiency diagnosed by exome sequencing
por: Haugarvoll, Kristoffer, et al.
Publicado: (2013)

No evidence of extensive non-CpG methylation in mtDNA
por: Guitton, Romain, et al.
Publicado: (2022)

Not every estimate counts – evaluation of cell composition estimation approaches in brain bulk tissue data
por: Toker, Lilah, et al.
Publicado: (2023)

Characterization of substantia nigra neurogenesis in homeostasis and dopaminergic degeneration: beneficial effects of the microneurotrophin BNN-20
por: Mourtzi, Theodora, et al.
Publicado: (2021)

Enhanced training protects memory against amnesia produced by concurrent inactivation of amygdala and striatum, amygdala and substantia nigra, or striatum and substantia nigra
por: Salado-Castillo, Rigoberto, et al.
Publicado: (2011)

NR-SAFE: a randomized, double-blind safety trial of high dose nicotinamide riboside in Parkinson’s disease
por: Berven, Haakon, et al.
Publicado: (2023)

Proteome analysis of human substantia nigra in Parkinson's disease
por: Werner, Cornelius J, et al.
Publicado: (2008)

Bidirectional Modulation of Substantia Nigra Activity by Motivational State
por: Rossi, Mark A., et al.
Publicado: (2013)

Operant Self-Stimulation of Dopamine Neurons in the Substantia Nigra
por: Rossi, Mark A., et al.
Publicado: (2013)

Epstein-Barr virus encephalitis with substantia nigra involvement
por: Çelik, Tamer, et al.
Publicado: (2015)

Mesencephalic origin of the rostral Substantia nigra pars reticulata
por: Madrigal, M. Pilar, et al.
Publicado: (2015)

Glucocerebrosidase Deficiency in Substantia Nigra of Parkinson Disease Brains
por: Gegg, Matthew E, et al.
Publicado: (2012)

Degeneration of the Substantia Nigra Following Ipsilateral Striatal Infarction
por: Ohtomo, Gaku, et al.
Publicado: (2017)

Proliferation of Inhibitory Input to the Substantia Nigra in Experimental Parkinsonism
por: Faynveitz, Anna, et al.
Publicado: (2019)

Mitochondrial respiratory chain deficiency correlates with the severity of neuropathology in sporadic Creutzfeldt-Jakob disease
por: Flønes, Irene H., et al.
Publicado: (2020)

Using urine to diagnose large‐scale mtDNA deletions in adult patients
por: Varhaug, Kristin N., et al.
Publicado: (2020)

Complement activation in the Parkinson's disease substantia nigra: an immunocytochemical study
por: Loeffler, David A, et al.
Publicado: (2006)

Parcellation of the human substantia nigra based on anatomical connectivity to the striatum()
por: Chowdhury, Rumana, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_c6svgp5jttcl6jbla5u4kij5ac