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Body Mass Index and the Risk of Cardiovascular and All-Cause Mortality Among Patients With Hypertension: A Population-Based Prospective Cohort Study Among Adults in Beijing, China
BACKGROUND: Studies on the association between body mass index (BMI) and death risk among patients with hypertension are limited, and the results are inconsistent. We investigated the association between BMI and cardiovascular disease (CVD) and all-cause mortality among hypertensive patients in a po...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Japan Epidemiological Association
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5121434/ https://www.ncbi.nlm.nih.gov/pubmed/27431649 http://dx.doi.org/10.2188/jea.JE20150323 |
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author | Li, Kuibao Yao, Chonghua Yang, Xinchun Di, Xuan Li, Na Dong, Lei Xu, Li Zheng, Meili |
author_facet | Li, Kuibao Yao, Chonghua Yang, Xinchun Di, Xuan Li, Na Dong, Lei Xu, Li Zheng, Meili |
author_sort | Li, Kuibao |
collection | PubMed |
description | BACKGROUND: Studies on the association between body mass index (BMI) and death risk among patients with hypertension are limited, and the results are inconsistent. We investigated the association between BMI and cardiovascular disease (CVD) and all-cause mortality among hypertensive patients in a population of Beijing, China. METHODS: We conducted a prospective cohort study of 2535 patients with hypertension aged 40 to 91 years from Beijing, China. Participants with a history of CVD at baseline were excluded from analysis. Cox proportional hazards regression models were used to estimate the association of different levels of BMI stratification with CVD and all-cause mortality. RESULTS: During a mean follow-up of 8.1 years, 486 deaths were identified, including 233 cases of CVD death. The multivariable-adjusted hazards ratios for all-cause mortality associated with BMI levels (<20, 20–22, 22–24, 24–26 [reference group], 26–28, 28–30, and ≥30 kg/m(2)) were 2.03 (95% confidence interval [CI], 1.48–2.78), 1.61 (95% CI, 1.18–2.20), 1.30 (95% CI, 0.95–1.78), 1.00 (reference), 1.12 (95% CI, 0.77–1.64), 1.33 (95% CI, 0.90–1.95), and 1.66 (95% CI, 1.10–2.49), respectively. When stratified by age, sex, or smoking status, the U-shaped association was still present in each subgroup (P > 0.05 for all interactions). Regarding the association of BMI with CVD mortality, a U-shaped trend was also observed. CONCLUSIONS: The present study showed a U-shaped association of BMI with CVD and all-cause mortality among patients with hypertension. A lowest risk of all-cause mortality was found among hypertensive patients with BMI between 24 and 26 kg/m(2). |
format | Online Article Text |
id | pubmed-5121434 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Japan Epidemiological Association |
record_format | MEDLINE/PubMed |
spelling | pubmed-51214342016-12-05 Body Mass Index and the Risk of Cardiovascular and All-Cause Mortality Among Patients With Hypertension: A Population-Based Prospective Cohort Study Among Adults in Beijing, China Li, Kuibao Yao, Chonghua Yang, Xinchun Di, Xuan Li, Na Dong, Lei Xu, Li Zheng, Meili J Epidemiol Original Article BACKGROUND: Studies on the association between body mass index (BMI) and death risk among patients with hypertension are limited, and the results are inconsistent. We investigated the association between BMI and cardiovascular disease (CVD) and all-cause mortality among hypertensive patients in a population of Beijing, China. METHODS: We conducted a prospective cohort study of 2535 patients with hypertension aged 40 to 91 years from Beijing, China. Participants with a history of CVD at baseline were excluded from analysis. Cox proportional hazards regression models were used to estimate the association of different levels of BMI stratification with CVD and all-cause mortality. RESULTS: During a mean follow-up of 8.1 years, 486 deaths were identified, including 233 cases of CVD death. The multivariable-adjusted hazards ratios for all-cause mortality associated with BMI levels (<20, 20–22, 22–24, 24–26 [reference group], 26–28, 28–30, and ≥30 kg/m(2)) were 2.03 (95% confidence interval [CI], 1.48–2.78), 1.61 (95% CI, 1.18–2.20), 1.30 (95% CI, 0.95–1.78), 1.00 (reference), 1.12 (95% CI, 0.77–1.64), 1.33 (95% CI, 0.90–1.95), and 1.66 (95% CI, 1.10–2.49), respectively. When stratified by age, sex, or smoking status, the U-shaped association was still present in each subgroup (P > 0.05 for all interactions). Regarding the association of BMI with CVD mortality, a U-shaped trend was also observed. CONCLUSIONS: The present study showed a U-shaped association of BMI with CVD and all-cause mortality among patients with hypertension. A lowest risk of all-cause mortality was found among hypertensive patients with BMI between 24 and 26 kg/m(2). Japan Epidemiological Association 2016-12-05 /pmc/articles/PMC5121434/ /pubmed/27431649 http://dx.doi.org/10.2188/jea.JE20150323 Text en © 2016 Kuibao Li et al. http://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the terms of Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Original Article Li, Kuibao Yao, Chonghua Yang, Xinchun Di, Xuan Li, Na Dong, Lei Xu, Li Zheng, Meili Body Mass Index and the Risk of Cardiovascular and All-Cause Mortality Among Patients With Hypertension: A Population-Based Prospective Cohort Study Among Adults in Beijing, China |
title | Body Mass Index and the Risk of Cardiovascular and All-Cause Mortality Among Patients With Hypertension: A Population-Based Prospective Cohort Study Among Adults in Beijing, China |
title_full | Body Mass Index and the Risk of Cardiovascular and All-Cause Mortality Among Patients With Hypertension: A Population-Based Prospective Cohort Study Among Adults in Beijing, China |
title_fullStr | Body Mass Index and the Risk of Cardiovascular and All-Cause Mortality Among Patients With Hypertension: A Population-Based Prospective Cohort Study Among Adults in Beijing, China |
title_full_unstemmed | Body Mass Index and the Risk of Cardiovascular and All-Cause Mortality Among Patients With Hypertension: A Population-Based Prospective Cohort Study Among Adults in Beijing, China |
title_short | Body Mass Index and the Risk of Cardiovascular and All-Cause Mortality Among Patients With Hypertension: A Population-Based Prospective Cohort Study Among Adults in Beijing, China |
title_sort | body mass index and the risk of cardiovascular and all-cause mortality among patients with hypertension: a population-based prospective cohort study among adults in beijing, china |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5121434/ https://www.ncbi.nlm.nih.gov/pubmed/27431649 http://dx.doi.org/10.2188/jea.JE20150323 |
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