Nonislet Cell Tumor Hypoglycemia in a Patient with Adrenal Cortical Carcinoma

Nonislet cell tumor hypoglycemia (NICTH) is a rare but serious paraneoplastic syndrome in which a tumor secretes incompletely processed precursors of insulin-like growth factor-II (IGF-II), causing hypoglycemia. Here, we report an exceptional case of NICTH caused by nonfunctioning adrenocortical car...

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Autores principales: Kim, Se Won, Lee, Seung-Eun, Oh, Young Lyun, Kim, Seokhwi, Park, Sun Hee, Kim, Jae Hyeon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2016
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5121447/
https://www.ncbi.nlm.nih.gov/pubmed/27957352
http://dx.doi.org/10.1155/2016/5731417
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author Kim, Se Won
Lee, Seung-Eun
Oh, Young Lyun
Kim, Seokhwi
Park, Sun Hee
Kim, Jae Hyeon
author_facet Kim, Se Won
Lee, Seung-Eun
Oh, Young Lyun
Kim, Seokhwi
Park, Sun Hee
Kim, Jae Hyeon
author_sort Kim, Se Won
collection PubMed
description Nonislet cell tumor hypoglycemia (NICTH) is a rare but serious paraneoplastic syndrome in which a tumor secretes incompletely processed precursors of insulin-like growth factor-II (IGF-II), causing hypoglycemia. Here, we report an exceptional case of NICTH caused by nonfunctioning adrenocortical carcinoma in a 39-year-old male with recurrent hypoglycemia. The patient's serum IGF-II/IGF-I ratio had increased to 27.8. The serum level of the IGF-II/IGF-I ratio was normalized after removal of the tumor, and the hypoglycemic attacks no longer occurred after the operation.
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spelling pubmed-51214472016-12-12 Nonislet Cell Tumor Hypoglycemia in a Patient with Adrenal Cortical Carcinoma Kim, Se Won Lee, Seung-Eun Oh, Young Lyun Kim, Seokhwi Park, Sun Hee Kim, Jae Hyeon Case Rep Endocrinol Case Report Nonislet cell tumor hypoglycemia (NICTH) is a rare but serious paraneoplastic syndrome in which a tumor secretes incompletely processed precursors of insulin-like growth factor-II (IGF-II), causing hypoglycemia. Here, we report an exceptional case of NICTH caused by nonfunctioning adrenocortical carcinoma in a 39-year-old male with recurrent hypoglycemia. The patient's serum IGF-II/IGF-I ratio had increased to 27.8. The serum level of the IGF-II/IGF-I ratio was normalized after removal of the tumor, and the hypoglycemic attacks no longer occurred after the operation. Hindawi Publishing Corporation 2016 2016-11-10 /pmc/articles/PMC5121447/ /pubmed/27957352 http://dx.doi.org/10.1155/2016/5731417 Text en Copyright © 2016 Se Won Kim et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Kim, Se Won
Lee, Seung-Eun
Oh, Young Lyun
Kim, Seokhwi
Park, Sun Hee
Kim, Jae Hyeon
Nonislet Cell Tumor Hypoglycemia in a Patient with Adrenal Cortical Carcinoma
title Nonislet Cell Tumor Hypoglycemia in a Patient with Adrenal Cortical Carcinoma
title_full Nonislet Cell Tumor Hypoglycemia in a Patient with Adrenal Cortical Carcinoma
title_fullStr Nonislet Cell Tumor Hypoglycemia in a Patient with Adrenal Cortical Carcinoma
title_full_unstemmed Nonislet Cell Tumor Hypoglycemia in a Patient with Adrenal Cortical Carcinoma
title_short Nonislet Cell Tumor Hypoglycemia in a Patient with Adrenal Cortical Carcinoma
title_sort nonislet cell tumor hypoglycemia in a patient with adrenal cortical carcinoma
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5121447/
https://www.ncbi.nlm.nih.gov/pubmed/27957352
http://dx.doi.org/10.1155/2016/5731417
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