Downregulation of Renal G Protein–Coupled Receptor Kinase Type 4 Expression via Ultrasound‐Targeted Microbubble Destruction Lowers Blood Pressure in Spontaneously Hypertensive Rats

BACKGROUND: G protein–coupled receptor kinase type 4 (GRK4) plays a vital role in the long‐term control of blood pressure (BP) and sodium excretion by regulating renal G protein–coupled receptor phosphorylation, including dopamine type 1 receptor (D(1)R). Ultrasound‐targeted microbubble destruction...

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Detalles Bibliográficos
Autores principales: Huang, Hefei, Li, Xiaolong, Zheng, Shuo, Chen, Yue, Chen, Caiyu, Wang, Jialiang, Tong, Haipeng, Zhou, Lin, Yang, Jian, Zeng, Chunyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5121504/
https://www.ncbi.nlm.nih.gov/pubmed/27792639
http://dx.doi.org/10.1161/JAHA.116.004028

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5121504/
https://www.ncbi.nlm.nih.gov/pubmed/27792639
http://dx.doi.org/10.1161/JAHA.116.004028

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