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The Association of DRD2 with Insight Problem Solving

Although the insight phenomenon has attracted great attention from psychologists, it is still largely unknown whether its variation in well-functioning human adults has a genetic basis. Several lines of evidence suggest that genes involved in dopamine (DA) transmission might be potential candidates....

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Detalles Bibliográficos
Autores principales: Zhang, Shun, Zhang, Jinghuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5121534/
https://www.ncbi.nlm.nih.gov/pubmed/27933030
http://dx.doi.org/10.3389/fpsyg.2016.01865
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author Zhang, Shun
Zhang, Jinghuan
author_facet Zhang, Shun
Zhang, Jinghuan
author_sort Zhang, Shun
collection PubMed
description Although the insight phenomenon has attracted great attention from psychologists, it is still largely unknown whether its variation in well-functioning human adults has a genetic basis. Several lines of evidence suggest that genes involved in dopamine (DA) transmission might be potential candidates. The present study explored for the first time the association of dopamine D2 receptor gene (DRD2) with insight problem solving. Fifteen single-nucleotide polymorphisms (SNPs) covering DRD2 were genotyped in 425 unrelated healthy Chinese undergraduates, and were further tested for association with insight problem solving. Both single SNP and haplotype analysis revealed several associations of DRD2 SNPs and haplotypes with insight problem solving. In conclusion, the present study provides the first evidence for the involvement of DRD2 in insight problem solving, future studies are necessary to validate these findings.
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spelling pubmed-51215342016-12-08 The Association of DRD2 with Insight Problem Solving Zhang, Shun Zhang, Jinghuan Front Psychol Psychology Although the insight phenomenon has attracted great attention from psychologists, it is still largely unknown whether its variation in well-functioning human adults has a genetic basis. Several lines of evidence suggest that genes involved in dopamine (DA) transmission might be potential candidates. The present study explored for the first time the association of dopamine D2 receptor gene (DRD2) with insight problem solving. Fifteen single-nucleotide polymorphisms (SNPs) covering DRD2 were genotyped in 425 unrelated healthy Chinese undergraduates, and were further tested for association with insight problem solving. Both single SNP and haplotype analysis revealed several associations of DRD2 SNPs and haplotypes with insight problem solving. In conclusion, the present study provides the first evidence for the involvement of DRD2 in insight problem solving, future studies are necessary to validate these findings. Frontiers Media S.A. 2016-11-24 /pmc/articles/PMC5121534/ /pubmed/27933030 http://dx.doi.org/10.3389/fpsyg.2016.01865 Text en Copyright © 2016 Zhang and Zhang. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Psychology
Zhang, Shun
Zhang, Jinghuan
The Association of DRD2 with Insight Problem Solving
title The Association of DRD2 with Insight Problem Solving
title_full The Association of DRD2 with Insight Problem Solving
title_fullStr The Association of DRD2 with Insight Problem Solving
title_full_unstemmed The Association of DRD2 with Insight Problem Solving
title_short The Association of DRD2 with Insight Problem Solving
title_sort association of drd2 with insight problem solving
topic Psychology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5121534/
https://www.ncbi.nlm.nih.gov/pubmed/27933030
http://dx.doi.org/10.3389/fpsyg.2016.01865
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