Febrile Neutropenia with Thrombocytopenia after Infliximab Induction in a Patient with Ulcerative Colitis

A 34-year-old female with left-sided ulcerative colitis (UC) developed severe febrile neutropenia/thrombocytopenia soon after infliximab induction therapy. There was no other plausible cause of the cell line abnormalities other than an accurate temporal association with infliximab administration. Su...

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Detalles Bibliográficos
Autores principales: Gomez, Gustavo, Umar, Shifa, Bilal, Mohammad, Strahotin, Cristina, Clarke, Kofi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: S. Karger AG 2016
Materias:
Single Case
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5121559/
https://www.ncbi.nlm.nih.gov/pubmed/27920647
http://dx.doi.org/10.1159/000448071
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author Gomez, Gustavo
Umar, Shifa
Bilal, Mohammad
Strahotin, Cristina
Clarke, Kofi
author_facet Gomez, Gustavo
Umar, Shifa
Bilal, Mohammad
Strahotin, Cristina
Clarke, Kofi
author_sort Gomez, Gustavo
collection PubMed
description A 34-year-old female with left-sided ulcerative colitis (UC) developed severe febrile neutropenia/thrombocytopenia soon after infliximab induction therapy. There was no other plausible cause of the cell line abnormalities other than an accurate temporal association with infliximab administration. Supportive care, broad-spectrum antibiotic, and single dose of filgrastim was given on day 5 of admission due to persistently low absolute neutrophil count and fevers. The cell lines recovered, fever resolved and the patient made a complete clinical recovery. Clinicians should be aware of this potential life-threatening inflixmab side effect previously unreported in adults with UC.
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spelling pubmed-51215592016-12-05 Febrile Neutropenia with Thrombocytopenia after Infliximab Induction in a Patient with Ulcerative Colitis Gomez, Gustavo Umar, Shifa Bilal, Mohammad Strahotin, Cristina Clarke, Kofi Case Rep Gastroenterol Single Case A 34-year-old female with left-sided ulcerative colitis (UC) developed severe febrile neutropenia/thrombocytopenia soon after infliximab induction therapy. There was no other plausible cause of the cell line abnormalities other than an accurate temporal association with infliximab administration. Supportive care, broad-spectrum antibiotic, and single dose of filgrastim was given on day 5 of admission due to persistently low absolute neutrophil count and fevers. The cell lines recovered, fever resolved and the patient made a complete clinical recovery. Clinicians should be aware of this potential life-threatening inflixmab side effect previously unreported in adults with UC. S. Karger AG 2016-10-18 /pmc/articles/PMC5121559/ /pubmed/27920647 http://dx.doi.org/10.1159/000448071 Text en Copyright © 2016 by S. Karger AG, Basel http://creativecommons.org/licenses/by-nc/4.0/ This article is licensed under the Creative Commons Attribution-NonCommercial-4.0 International License (CC BY-NC) (http://www.karger.com/Services/OpenAccessLicense). Usage and distribution for commercial purposes requires written permission.
spellingShingle Single Case
Gomez, Gustavo
Umar, Shifa
Bilal, Mohammad
Strahotin, Cristina
Clarke, Kofi
Febrile Neutropenia with Thrombocytopenia after Infliximab Induction in a Patient with Ulcerative Colitis
title Febrile Neutropenia with Thrombocytopenia after Infliximab Induction in a Patient with Ulcerative Colitis
title_full Febrile Neutropenia with Thrombocytopenia after Infliximab Induction in a Patient with Ulcerative Colitis
title_fullStr Febrile Neutropenia with Thrombocytopenia after Infliximab Induction in a Patient with Ulcerative Colitis
title_full_unstemmed Febrile Neutropenia with Thrombocytopenia after Infliximab Induction in a Patient with Ulcerative Colitis
title_short Febrile Neutropenia with Thrombocytopenia after Infliximab Induction in a Patient with Ulcerative Colitis
title_sort febrile neutropenia with thrombocytopenia after infliximab induction in a patient with ulcerative colitis
topic Single Case
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5121559/
https://www.ncbi.nlm.nih.gov/pubmed/27920647
http://dx.doi.org/10.1159/000448071
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