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The mevalonate pathway regulates primitive streak formation via protein farnesylation

The primitive streak in peri-implantation embryos forms the mesoderm and endoderm and controls cell differentiation. The metabolic cues regulating primitive streak formation remain largely unknown. Here we utilised a mouse embryonic stem (ES) cell differentiation system and a library of well-charact...

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Detalles Bibliográficos
Autores principales:	Okamoto-Uchida, Yoshimi, Yu, Ruoxing, Miyamura, Norio, Arima, Norie, Ishigami-Yuasa, Mari, Kagechika, Hiroyuki, Yoshida, Suguru, Hosoya, Takamitsu, Nawa, Makiko, Kasama, Takeshi, Asaoka, Yoichi, Alois, Reiner Wimmer, Elling, Ulrich, Penninger, Josef M., Nishina, Sachiko, Azuma, Noriyuki, Nishina, Hiroshi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5121603/ https://www.ncbi.nlm.nih.gov/pubmed/27883036 http://dx.doi.org/10.1038/srep37697

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