Non-RVD mutations that enhance the dynamics of the TAL repeat array along the superhelical axis improve TALEN genome editing efficacy

Transcription activator-like effector (TALE) nuclease (TALEN) is widely used as a tool in genome editing. The DNA binding part of TALEN consists of a tandem array of TAL-repeats that form a right-handed superhelix. Each TAL-repeat recognises a specific base by the repeat variable diresidue (RVD) at...

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Detalles Bibliográficos
Autores principales: Tochio, Naoya, Umehara, Kohei, Uewaki, Jun-ichi, Flechsig, Holger, Kondo, Masaharu, Dewa, Takehisa, Sakuma, Tetsushi, Yamamoto, Takashi, Saitoh, Takashi, Togashi, Yuichi, Tate, Shin-ichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5121632/
https://www.ncbi.nlm.nih.gov/pubmed/27883072
http://dx.doi.org/10.1038/srep37887

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