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V(D)J recombination process and the Pre-B to immature B-cells transition are altered in Fanca(−/−) mice

B-lymphocytes in the bone marrow (BM) must generate a functional B-cell receptor and overcome the negative selection induced by reactivity with autoantigens. Two rounds of DNA recombination are required for the production of functional immunoglobulin heavy (Ig-HCs) and light (LCs) chains necessary f...

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Detalles Bibliográficos
Autores principales:	Nguyen, Thuy Vy, Pawlikowska, Patrycja, Firlej, Virginie, Rosselli, Filippo, Aoufouchi, Saïd
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5121645/ https://www.ncbi.nlm.nih.gov/pubmed/27883081 http://dx.doi.org/10.1038/srep36906

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