Cargando…

Sphingosine 1-phosphate lyase ablation disrupts presynaptic architecture and function via an ubiquitin- proteasome mediated mechanism

The bioactive lipid sphingosine 1-phosphate (S1P) is a degradation product of sphingolipids that are particularly abundant in neurons. We have shown previously that neuronal S1P accumulation is toxic leading to ER-stress and an increase in intracellular calcium. To clarify the neuronal function of S...

Descripción completa

Detalles Bibliográficos
Autores principales:	Mitroi, Daniel N., Deutschmann, André U., Raucamp, Maren, Karunakaran, Indulekha, Glebov, Konstantine, Hans, Michael, Walter, Jochen, Saba, Julie, Gräler, Markus, Ehninger, Dan, Sopova, Elena, Shupliakov, Oleg, Swandulla, Dieter, van Echten-Deckert, Gerhild
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5121647/ https://www.ncbi.nlm.nih.gov/pubmed/27883090 http://dx.doi.org/10.1038/srep37064

Ejemplares similares

SGPL1 (sphingosine phosphate lyase 1) modulates neuronal autophagy via phosphatidylethanolamine production
por: Mitroi, Daniel N., et al.
Publicado: (2017)

Neurodegeneration Caused by S1P-Lyase Deficiency Involves Calcium-Dependent Tau Pathology and Abnormal Histone Acetylation
por: Alam, Shah, et al.
Publicado: (2020)

Sphingosine‐1‐phosphate‐lyase deficiency affects glucose metabolism in a way that abets oncogenesis
por: Afsar, Sumaiya Y., et al.
Publicado: (2022)

Sphingosine-1-phosphate links glycosphingolipid metabolism to neurodegeneration via a calpain-mediated mechanism
por: Hagen, N, et al.
Publicado: (2011)

S1P Lyase Deficiency in the Brain Promotes Astrogliosis and NLRP3 Inflammasome Activation via Purinergic Signaling
por: Alam, Shah, et al.
Publicado: (2023)

Characterization of cholesterol homeostasis in sphingosine-1-phosphate lyase-deficient fibroblasts reveals a Niemann-Pick disease type C-like phenotype with enhanced lysosomal Ca(2+) storage
por: Vienken, Hans, et al.
Publicado: (2017)

Sphingosine-1 Phosphate Lyase Regulates Sensitivity of Pancreatic Beta-Cells to Lipotoxicity
por: Tang, Yadi, et al.
Publicado: (2021)

Special Issue on “Sphingolipids: From Pathology to Therapeutic Perspectives”
por: van Echten-Deckert, Gerhild
Publicado: (2020)

Neurological Consequences of Sphingosine Phosphate Lyase Insufficiency
por: Atreya, Krishan B., et al.
Publicado: (2022)

Cross-talk of membrane lipids and Alzheimer-related proteins
por: Walter, Jochen, et al.
Publicado: (2013)

Dendritic cell sphingosine-1-phosphate lyase regulates thymic egress
por: Zamora-Pineda, Jesus, et al.
Publicado: (2016)

Sphingolipid metabolism in the development and progression of cancer: one cancer's help is another's hindrance
por: Piazzesi, Antonia, et al.
Publicado: (2021)

S1P Released by SGPL1-Deficient Astrocytes Enhances Astrocytic ATP Production via S1PR(2,4), Thus Keeping Autophagy in Check: Potential Consequences for Brain Health
por: Alam, Shah, et al.
Publicado: (2023)

Sphingosine-1-Phosphate (S1P) Lyase Inhibition Aggravates Atherosclerosis and Induces Plaque Rupture in ApoE(−/−) Mice
por: Keul, Petra, et al.
Publicado: (2022)

Taking a Back Seat: Synaptic Vesicle Clustering in Presynaptic Terminals
por: Pechstein, Arndt, et al.
Publicado: (2010)

Dataset on the mass spectrometry-based proteomic profiling of the kidney from wild type and the dystrophic mdx-4cv mouse model of X-linked muscular dystrophy
por: Dowling, Paul, et al.
Publicado: (2020)

Recent Insight into the Role of Sphingosine-1-Phosphate Lyase in Neurodegeneration
por: Wieczorek, Iga, et al.
Publicado: (2023)

Regulation of cellular sphingosine-1-phosphate by sphingosine kinase 1 and sphingosine-1-phopshate lyase determines chemotherapy resistance in gastroesophageal cancer
por: Matula, Kasia, et al.
Publicado: (2015)

Reduced sphingosine kinase-1 and enhanced sphingosine 1-phosphate lyase expression demonstrate deregulated sphingosine 1-phosphate signaling in Alzheimer’s disease
por: Ceccom, Johnatan, et al.
Publicado: (2014)

Acquired modification of sphingosine-1-phosphate lyase activity is not related to adrenal insufficiency
por: Sunter, Gulin, et al.
Publicado: (2018)

Sphingolipids in Ventilator Induced Lung Injury: Role of Sphingosine-1-Phosphate Lyase
por: Suryadevara, Vidyani, et al.
Publicado: (2018)

Sphingosine-1-phosphate lyase (SGPL1) deficiency is associated with mitochondrial dysfunction
por: Maharaj, A., et al.
Publicado: (2020)

Sphingosine 1-Phosphate Lyase in the Developing and Injured Nervous System: a Dichotomy?
por: Xiao, Junhua
Publicado: (2023)

Deficiency of sphingosine-1-phosphate receptor 3 does not affect the skeletal phenotype of mice lacking sphingosine-1-phosphate lyase
por: Heckt, Timo, et al.
Publicado: (2019)

Sphingosine Phosphate Lyase Regulates Murine Embryonic Stem Cell Proliferation and Pluripotency through an S1P(2)/STAT3 Signaling Pathway
por: Smith, Gaelen S., et al.
Publicado: (2013)

Partial Deficiency of Sphingosine-1-Phosphate Lyase Confers Protection in Experimental Autoimmune Encephalomyelitis
por: Billich, Andreas, et al.
Publicado: (2013)

Characterization of homologous sphingosine-1-phosphate lyase isoforms in the bacterial pathogen Burkholderia pseudomallei
por: McLean, Christopher J., et al.
Publicado: (2017)

Mitochondrial sphingosine-1-phosphate lyase is essential for phosphatidylethanolamine synthesis and survival of Trypanosoma brucei
por: Dawoody Nejad, Ladan, et al.
Publicado: (2020)

Sphingosine 1- Phosphate Lyase Insufficiency Syndrome (SPLIS); A Role in Multiple Endocrinopathies
por: Wai Kwong, Ruth Ming, et al.
Publicado: (2021)

Sphingosine 1‐phosphate lyase facilitates cancer progression through converting sphingolipids to glycerophospholipids
por: Uranbileg, Baasanjav, et al.
Publicado: (2022)

Detection of endogenous lipids in chicken feathers distinct from preen gland constituents
por: Zeisler-Diehl, Viktoria, et al.
Publicado: (2020)

Vitamin B6 prevents excessive inflammation by reducing accumulation of sphingosine‐1‐phosphate in a sphingosine‐1‐phosphate lyase–dependent manner
por: Du, Xialin, et al.
Publicado: (2020)

Sphingosine Phosphate Lyase Is Upregulated in Duchenne Muscular Dystrophy, and Its Inhibition Early in Life Attenuates Inflammation and Dystrophy in Mdx Mice
por: De la Garza-Rodea, Anabel S., et al.
Publicado: (2022)

Sphingosine-1-Phosphate Lyase Deficient Cells as a Tool to Study Protein Lipid Interactions
por: Gerl, Mathias J., et al.
Publicado: (2016)

The Sphingosine-1-Phosphate Lyase (LegS2) Contributes to the Restriction of Legionella pneumophila in Murine Macrophages
por: Abu Khweek, Arwa, et al.
Publicado: (2016)

Suppression of sphingosine 1-phosphate lyase retards the liver regeneration in mice after partial hepatectomy
por: Kageyama, Yuko, et al.
Publicado: (2020)

A Sphingosine-1-Phosphate Lyase Mutation Associated With Congenital Nephrotic Syndrome and Multiple Endocrinopathy
por: Maharaj, Avinaash, et al.
Publicado: (2020)

AAV-SPL 2.0, a Modified Adeno-Associated Virus Gene Therapy Agent for the Treatment of Sphingosine Phosphate Lyase Insufficiency Syndrome
por: Khan, Ranjha, et al.
Publicado: (2023)

Resensitising proteasome inhibitor-resistant myeloma with sphingosine kinase 2 inhibition
por: Bennett, Melissa K., et al.
Publicado: (2021)

The proteasome controls presynaptic differentiation through modulation of an on-site pool of polyubiquitinated conjugates
por: Pinto, Maria J., et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_2f8k9i13rltqg5pq1q8b4qkvni