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Interaction between β-hexachlorocyclohexane and ADIPOQ genotypes contributes to the risk of type 2 diabetes mellitus in East Chinese adults

Growing evidence links environmental exposure to hexachlorocyclohexanes (HCHs) to the risk of type 2 diabetes mellitus (T2DM), and ADIPOQ that encodes adiponectin is considered as an important gene for T2DM. However, the role of ADIPOQ-HCH interaction on T2DM risk remains unclear. Thus, a paired cas...

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Autores principales: Li, Shushu, Wang, Xichen, Yang, Lu, Yao, Shen, Zhang, Ruyang, Xiao, Xue, Zhang, Zhan, Wang, Li, Xu, Qiujin, Wang, Shou-Lin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5121886/
https://www.ncbi.nlm.nih.gov/pubmed/27883041
http://dx.doi.org/10.1038/srep37769
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author Li, Shushu
Wang, Xichen
Yang, Lu
Yao, Shen
Zhang, Ruyang
Xiao, Xue
Zhang, Zhan
Wang, Li
Xu, Qiujin
Wang, Shou-Lin
author_facet Li, Shushu
Wang, Xichen
Yang, Lu
Yao, Shen
Zhang, Ruyang
Xiao, Xue
Zhang, Zhan
Wang, Li
Xu, Qiujin
Wang, Shou-Lin
author_sort Li, Shushu
collection PubMed
description Growing evidence links environmental exposure to hexachlorocyclohexanes (HCHs) to the risk of type 2 diabetes mellitus (T2DM), and ADIPOQ that encodes adiponectin is considered as an important gene for T2DM. However, the role of ADIPOQ-HCH interaction on T2DM risk remains unclear. Thus, a paired case-control study was conducted in an East Chinese community. A total of 1446 subjects, including 723 cases and 723 controls matched on age, gender and residence, were enrolled, and 4 types of HCH isomers were measured in serum samples using GC-MS/MS. Additionally, 4 candidate ADIPOQ SNPs (rs182052, rs266729, rs6810075, and rs16861194) were genotyped by TaqMan assay, and plasma adiponectin was measured using ELISA. No associations between 4 SNPs and T2DM risk were found, but T2DM risk significantly increased with serum levels of β-HCH (P < 0.001). Furthermore, the synergistic interaction between β-HCH and rs182052 significantly increased T2DM risk (OR (I-additive model) = 2.20, OR (I-recessive model) = 2.13). Additionally, individuals carrying only rs182052 (A allele) with high levels of β-HCH had significant reduction in adiponectin levels (P = 0.016). These results indicate that the interaction between rs182052 and β-HCH might increase the risk of T2DM by jointly decreasing the adiponectin level and potentially trigger T2DM development.
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spelling pubmed-51218862016-11-28 Interaction between β-hexachlorocyclohexane and ADIPOQ genotypes contributes to the risk of type 2 diabetes mellitus in East Chinese adults Li, Shushu Wang, Xichen Yang, Lu Yao, Shen Zhang, Ruyang Xiao, Xue Zhang, Zhan Wang, Li Xu, Qiujin Wang, Shou-Lin Sci Rep Article Growing evidence links environmental exposure to hexachlorocyclohexanes (HCHs) to the risk of type 2 diabetes mellitus (T2DM), and ADIPOQ that encodes adiponectin is considered as an important gene for T2DM. However, the role of ADIPOQ-HCH interaction on T2DM risk remains unclear. Thus, a paired case-control study was conducted in an East Chinese community. A total of 1446 subjects, including 723 cases and 723 controls matched on age, gender and residence, were enrolled, and 4 types of HCH isomers were measured in serum samples using GC-MS/MS. Additionally, 4 candidate ADIPOQ SNPs (rs182052, rs266729, rs6810075, and rs16861194) were genotyped by TaqMan assay, and plasma adiponectin was measured using ELISA. No associations between 4 SNPs and T2DM risk were found, but T2DM risk significantly increased with serum levels of β-HCH (P < 0.001). Furthermore, the synergistic interaction between β-HCH and rs182052 significantly increased T2DM risk (OR (I-additive model) = 2.20, OR (I-recessive model) = 2.13). Additionally, individuals carrying only rs182052 (A allele) with high levels of β-HCH had significant reduction in adiponectin levels (P = 0.016). These results indicate that the interaction between rs182052 and β-HCH might increase the risk of T2DM by jointly decreasing the adiponectin level and potentially trigger T2DM development. Nature Publishing Group 2016-11-24 /pmc/articles/PMC5121886/ /pubmed/27883041 http://dx.doi.org/10.1038/srep37769 Text en Copyright © 2016, The Author(s) http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Li, Shushu
Wang, Xichen
Yang, Lu
Yao, Shen
Zhang, Ruyang
Xiao, Xue
Zhang, Zhan
Wang, Li
Xu, Qiujin
Wang, Shou-Lin
Interaction between β-hexachlorocyclohexane and ADIPOQ genotypes contributes to the risk of type 2 diabetes mellitus in East Chinese adults
title Interaction between β-hexachlorocyclohexane and ADIPOQ genotypes contributes to the risk of type 2 diabetes mellitus in East Chinese adults
title_full Interaction between β-hexachlorocyclohexane and ADIPOQ genotypes contributes to the risk of type 2 diabetes mellitus in East Chinese adults
title_fullStr Interaction between β-hexachlorocyclohexane and ADIPOQ genotypes contributes to the risk of type 2 diabetes mellitus in East Chinese adults
title_full_unstemmed Interaction between β-hexachlorocyclohexane and ADIPOQ genotypes contributes to the risk of type 2 diabetes mellitus in East Chinese adults
title_short Interaction between β-hexachlorocyclohexane and ADIPOQ genotypes contributes to the risk of type 2 diabetes mellitus in East Chinese adults
title_sort interaction between β-hexachlorocyclohexane and adipoq genotypes contributes to the risk of type 2 diabetes mellitus in east chinese adults
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5121886/
https://www.ncbi.nlm.nih.gov/pubmed/27883041
http://dx.doi.org/10.1038/srep37769
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