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p53 predominantly regulates IL-6 production and suppresses synovial inflammation in fibroblast-like synoviocytes and adjuvant-induced arthritis

BACKGROUND: Dominant-negative somatic mutations of p53 has been identified in the synovium of patients with rheumatoid arthritis (RA), in which interleukin (IL)-6 has been established as a pivotal inflammatory cytokine. The aim of this study was to clarify the significance of p53 in the longstanding...

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Detalles Bibliográficos
Autores principales:	Zhang, Ting, Li, Huihua, Shi, Juan, Li, Sha, Li, Muyuan, Zhang, Lei, Zheng, Leting, Zheng, Dexian, Tang, Fulin, Zhang, Xuan, Zhang, Fengchun, You, Xin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5121977/ https://www.ncbi.nlm.nih.gov/pubmed/27881147 http://dx.doi.org/10.1186/s13075-016-1161-4

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