Evaluating the role of maternal folic acid supplementation in modifying the effects of methylenetetrahydrofolate reductase (C677T and A1298C) gene polymorphisms in oral cleft children

BACKGROUND: We studied the role of maternal folic acid supplementation in modifying the effects of methylenetetrahydrofolate reductase (MTHFR C677T and A1298C) gene polymorphisms in Iranian children with oral clefts. MATERIALS AND METHODS: Forty-seven newborn infants with orofacial cleft and their m...

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Autores principales: Ebadifar, Asghar, Ameli, Nazila, KhorramKhorshid, Hamid Reza, Kamali, Koorosh, Zeinabadi, Mehdi Salehi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2016
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5121989/
https://www.ncbi.nlm.nih.gov/pubmed/27904604
http://dx.doi.org/10.4103/1735-1995.187307
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author Ebadifar, Asghar
Ameli, Nazila
KhorramKhorshid, Hamid Reza
Kamali, Koorosh
Zeinabadi, Mehdi Salehi
author_facet Ebadifar, Asghar
Ameli, Nazila
KhorramKhorshid, Hamid Reza
Kamali, Koorosh
Zeinabadi, Mehdi Salehi
author_sort Ebadifar, Asghar
collection PubMed
description BACKGROUND: We studied the role of maternal folic acid supplementation in modifying the effects of methylenetetrahydrofolate reductase (MTHFR C677T and A1298C) gene polymorphisms in Iranian children with oral clefts. MATERIALS AND METHODS: Forty-seven newborn infants with orofacial cleft and their mothers were selected randomly. Mothers were matched regarding dietary folate intake. The genotyping on venous blood was carried out. Consistency between maternal and child genotypes was analyzed. RESULTS: Genotype consistency was not statistically significant in both C677T and A1298C gene variants (P > 0.05). CONCLUSION: Maternal folic acid consumption may not have any significant effect on modifying C677T and A1298C polymorphisms in children.
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spelling pubmed-51219892016-11-30 Evaluating the role of maternal folic acid supplementation in modifying the effects of methylenetetrahydrofolate reductase (C677T and A1298C) gene polymorphisms in oral cleft children Ebadifar, Asghar Ameli, Nazila KhorramKhorshid, Hamid Reza Kamali, Koorosh Zeinabadi, Mehdi Salehi J Res Med Sci Short Communication BACKGROUND: We studied the role of maternal folic acid supplementation in modifying the effects of methylenetetrahydrofolate reductase (MTHFR C677T and A1298C) gene polymorphisms in Iranian children with oral clefts. MATERIALS AND METHODS: Forty-seven newborn infants with orofacial cleft and their mothers were selected randomly. Mothers were matched regarding dietary folate intake. The genotyping on venous blood was carried out. Consistency between maternal and child genotypes was analyzed. RESULTS: Genotype consistency was not statistically significant in both C677T and A1298C gene variants (P > 0.05). CONCLUSION: Maternal folic acid consumption may not have any significant effect on modifying C677T and A1298C polymorphisms in children. Medknow Publications & Media Pvt Ltd 2016-08-01 /pmc/articles/PMC5121989/ /pubmed/27904604 http://dx.doi.org/10.4103/1735-1995.187307 Text en Copyright: © 2016 Journal of Research in Medical Sciences http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.
spellingShingle Short Communication
Ebadifar, Asghar
Ameli, Nazila
KhorramKhorshid, Hamid Reza
Kamali, Koorosh
Zeinabadi, Mehdi Salehi
Evaluating the role of maternal folic acid supplementation in modifying the effects of methylenetetrahydrofolate reductase (C677T and A1298C) gene polymorphisms in oral cleft children
title Evaluating the role of maternal folic acid supplementation in modifying the effects of methylenetetrahydrofolate reductase (C677T and A1298C) gene polymorphisms in oral cleft children
title_full Evaluating the role of maternal folic acid supplementation in modifying the effects of methylenetetrahydrofolate reductase (C677T and A1298C) gene polymorphisms in oral cleft children
title_fullStr Evaluating the role of maternal folic acid supplementation in modifying the effects of methylenetetrahydrofolate reductase (C677T and A1298C) gene polymorphisms in oral cleft children
title_full_unstemmed Evaluating the role of maternal folic acid supplementation in modifying the effects of methylenetetrahydrofolate reductase (C677T and A1298C) gene polymorphisms in oral cleft children
title_short Evaluating the role of maternal folic acid supplementation in modifying the effects of methylenetetrahydrofolate reductase (C677T and A1298C) gene polymorphisms in oral cleft children
title_sort evaluating the role of maternal folic acid supplementation in modifying the effects of methylenetetrahydrofolate reductase (c677t and a1298c) gene polymorphisms in oral cleft children
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5121989/
https://www.ncbi.nlm.nih.gov/pubmed/27904604
http://dx.doi.org/10.4103/1735-1995.187307
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