Increased Set1 binding at the promoter induces aberrant epigenetic alterations and up-regulates cyclic adenosine 5'-monophosphate response element modulator alpha in systemic lupus erythematosus

BACKGROUND: Up-regulated cyclic adenosine 5'-monophosphate response element modulator α (CREMα) which can inhibit IL-2 and induce IL-17A in T cells plays a critical role in the pathogenesis of systemic lupus erythematosus (SLE). This research aimed to investigate the mechanisms regulating CREMα...

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Detalles Bibliográficos
Autores principales: Zhang, Qing, Ding, Shu, Zhang, Huilin, Long, Hai, Wu, Haijing, Zhao, Ming, Chan, Vera, Lau, Chak-Sing, Lu, Qianjin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5122196/
https://www.ncbi.nlm.nih.gov/pubmed/27904655
http://dx.doi.org/10.1186/s13148-016-0294-2

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