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NRAS germline variant G138R and multiple rare somatic mutations on APC in colorectal cancer patients in Taiwan by next generation sequencing

Colorectal cancer (CRC) arises from mutations in a subset of genes. We investigated the germline and somatic mutation spectrum of patients with CRC in Taiwan by using the AmpliSeq Cancer Hotspot Panel V2. Fifty paired freshly frozen stage 0–IV CRC tumors and adjacent normal tissue were collected. Bl...

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Detalles Bibliográficos
Autores principales:	Chang, Pi-Yueh, Chen, Jinn-Shiun, Chang, Nai-Chung, Chang, Shih-Cheng, Wang, Mei-Chia, Tsai, Shu-Hui, Wen, Ying-Hao, Tsai, Wen-Sy, Chan, Err-Cheng, Lu, Jang-Jih
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2016
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5122332/ https://www.ncbi.nlm.nih.gov/pubmed/27121310 http://dx.doi.org/10.18632/oncotarget.8885

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