A novel TRPV4-specific agonist inhibits monocyte adhesion and atherosclerosis

TRPV4 ion channel mediates vascular mechanosensitivity and vasodilation. Here, we sought to explore whether non-mechanical activation of TRPV4 could limit vascular inflammation and atherosclerosis. We found that GSK1016790A, a potent and specific small-molecule agonist of TRPV4, induces the phosphor...

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Detalles Bibliográficos
Autores principales: Xu, Suowen, Liu, Bin, Yin, Meimei, Koroleva, Marina, Mastrangelo, Michael, Ture, Sara, Morrell, Craig N., Zhang, David X., Fisher, Edward A., Jin, Zheng Gen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5122337/
https://www.ncbi.nlm.nih.gov/pubmed/27191895
http://dx.doi.org/10.18632/oncotarget.9376

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