Nuclear delivery of recombinant OCT4 by chitosan nanoparticles for transgene-free generation of protein-induced pluripotent stem cells

Protein-based reprogramming of somatic cells is a non-genetic approach for the generation of induced pluripotent stem cells (iPSCs), whereby reprogramming factors, such as OCT4, SOX2, KLF4 and c-MYC, are delivered as functional proteins. The technique is considered safer than transgenic methods, but...

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Detalles Bibliográficos
Autores principales: Tammam, Salma, Malak, Peter, Correa, Daphne, Rothfuss, Oliver, Hassan M.E., Azzazy, Lamprecht, Alf, Schulze-Osthoff, Klaus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5122344/
https://www.ncbi.nlm.nih.gov/pubmed/27183911
http://dx.doi.org/10.18632/oncotarget.9276

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