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Current perspectives between metabolic syndrome and cancer

Metabolic syndrome is a cluster of risk factors that lead to cardiovascular morbidity and mortality. Recent studies linked metabolic syndrome and several types of cancer. Although metabolic syndrome may not necessarily cause cancer, it is linked to poorer cancer outcomes including increased risk of...

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Detalles Bibliográficos
Autores principales: Micucci, Carla, Valli, Debora, Matacchione, Giulia, Catalano, Alfonso
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5122443/
https://www.ncbi.nlm.nih.gov/pubmed/27029038
http://dx.doi.org/10.18632/oncotarget.8341
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author Micucci, Carla
Valli, Debora
Matacchione, Giulia
Catalano, Alfonso
author_facet Micucci, Carla
Valli, Debora
Matacchione, Giulia
Catalano, Alfonso
author_sort Micucci, Carla
collection PubMed
description Metabolic syndrome is a cluster of risk factors that lead to cardiovascular morbidity and mortality. Recent studies linked metabolic syndrome and several types of cancer. Although metabolic syndrome may not necessarily cause cancer, it is linked to poorer cancer outcomes including increased risk of recurrence and overall mortality. This review tends to discuss the major biological and physiological alterations involved in the increase of incidence and mortality of cancer patients affected by metabolic syndrome. We focus on metabolic syndrome-associated visceral adiposity, hyperinsulinemia, hyperglycemia, insulin-like growth factor (IGF-I) pathway as well as estrogen signaling and inflammation. Several of these factors are also involved in carcinogenesis and cancer progression. A better understanding of the link between metabolic syndrome and cancer may provide new insight about oncogenesis. Moreover, prevention of metabolic syndrome – related alterations may be an important aspect in the management of cancer patients during simultaneous palliative care.
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spelling pubmed-51224432016-12-05 Current perspectives between metabolic syndrome and cancer Micucci, Carla Valli, Debora Matacchione, Giulia Catalano, Alfonso Oncotarget Review Metabolic syndrome is a cluster of risk factors that lead to cardiovascular morbidity and mortality. Recent studies linked metabolic syndrome and several types of cancer. Although metabolic syndrome may not necessarily cause cancer, it is linked to poorer cancer outcomes including increased risk of recurrence and overall mortality. This review tends to discuss the major biological and physiological alterations involved in the increase of incidence and mortality of cancer patients affected by metabolic syndrome. We focus on metabolic syndrome-associated visceral adiposity, hyperinsulinemia, hyperglycemia, insulin-like growth factor (IGF-I) pathway as well as estrogen signaling and inflammation. Several of these factors are also involved in carcinogenesis and cancer progression. A better understanding of the link between metabolic syndrome and cancer may provide new insight about oncogenesis. Moreover, prevention of metabolic syndrome – related alterations may be an important aspect in the management of cancer patients during simultaneous palliative care. Impact Journals LLC 2016-03-24 /pmc/articles/PMC5122443/ /pubmed/27029038 http://dx.doi.org/10.18632/oncotarget.8341 Text en Copyright: © 2016 Micucci et al. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Review
Micucci, Carla
Valli, Debora
Matacchione, Giulia
Catalano, Alfonso
Current perspectives between metabolic syndrome and cancer
title Current perspectives between metabolic syndrome and cancer
title_full Current perspectives between metabolic syndrome and cancer
title_fullStr Current perspectives between metabolic syndrome and cancer
title_full_unstemmed Current perspectives between metabolic syndrome and cancer
title_short Current perspectives between metabolic syndrome and cancer
title_sort current perspectives between metabolic syndrome and cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5122443/
https://www.ncbi.nlm.nih.gov/pubmed/27029038
http://dx.doi.org/10.18632/oncotarget.8341
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