Cargando…

The Relationship between the Size and the Invasion Depth of Tumors in Head and Neck Cutaneous Squamous Cell Carcinoma

BACKGROUND: Cutaneous squamous cell carcinoma (SCC), which occurs in keratinocytes of the epidermis and is the second most common skin cancer, has a more invasive growth pattern and higher potential to metastasize than basal cell carcinoma. Total excision of the primary tumor is the treatment of cho...

Descripción completa

Detalles Bibliográficos
Autores principales: Lee, Sam Yong, Hwang, Won Joo, Kim, Kyung Pil, Kim, Hong Min, Hwang, Jae Ha, Kim, Kwang Seog
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Society of Plastic and Reconstructive Surgeons 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5122543/
https://www.ncbi.nlm.nih.gov/pubmed/27896185
http://dx.doi.org/10.5999/aps.2016.43.6.538
_version_ 1782469596532441088
author Lee, Sam Yong
Hwang, Won Joo
Kim, Kyung Pil
Kim, Hong Min
Hwang, Jae Ha
Kim, Kwang Seog
author_facet Lee, Sam Yong
Hwang, Won Joo
Kim, Kyung Pil
Kim, Hong Min
Hwang, Jae Ha
Kim, Kwang Seog
author_sort Lee, Sam Yong
collection PubMed
description BACKGROUND: Cutaneous squamous cell carcinoma (SCC), which occurs in keratinocytes of the epidermis and is the second most common skin cancer, has a more invasive growth pattern and higher potential to metastasize than basal cell carcinoma. Total excision of the primary tumor is the treatment of choice. For clear excision of the tumor, invasion depth is one of the most important factors. This study was conducted to clarify the relationship between the size and the invasion depth of cutaneous SCC. METHODS: Twenty-six cases were collected for this prospective study. Frozen biopsies were examined after complete resection of the tumor, followed by histological confirmation by pathological examination. The major and minor axis lengths of the tumor, the invasion depth, and the level of invasion were measured. Recurrence or metastasis was recorded through regular follow-up. RESULTS: The Pearson correlation coefficient was used for statistical analysis. Significant results were observed for the relationship between the major and minor axis lengths and the invasion depth of the tumor (0.747, 0.773). No cases of recurrence or metastasis were observed. CONCLUSIONS: In head and neck cutaneous SCC, the invasion depth of the tumor is closely related to the major and minor axis lengths of the tumor. Therefore, the invasion depth of the tumor can be estimated by measuring the size of the tumor, and a standard vertical safety margin for head and neck cutaneous SCC can be established, which could be helpful in the development of a preoperative reconstruction plan.
format Online
Article
Text
id pubmed-5122543
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher The Korean Society of Plastic and Reconstructive Surgeons
record_format MEDLINE/PubMed
spelling pubmed-51225432016-11-28 The Relationship between the Size and the Invasion Depth of Tumors in Head and Neck Cutaneous Squamous Cell Carcinoma Lee, Sam Yong Hwang, Won Joo Kim, Kyung Pil Kim, Hong Min Hwang, Jae Ha Kim, Kwang Seog Arch Plast Surg Original Article BACKGROUND: Cutaneous squamous cell carcinoma (SCC), which occurs in keratinocytes of the epidermis and is the second most common skin cancer, has a more invasive growth pattern and higher potential to metastasize than basal cell carcinoma. Total excision of the primary tumor is the treatment of choice. For clear excision of the tumor, invasion depth is one of the most important factors. This study was conducted to clarify the relationship between the size and the invasion depth of cutaneous SCC. METHODS: Twenty-six cases were collected for this prospective study. Frozen biopsies were examined after complete resection of the tumor, followed by histological confirmation by pathological examination. The major and minor axis lengths of the tumor, the invasion depth, and the level of invasion were measured. Recurrence or metastasis was recorded through regular follow-up. RESULTS: The Pearson correlation coefficient was used for statistical analysis. Significant results were observed for the relationship between the major and minor axis lengths and the invasion depth of the tumor (0.747, 0.773). No cases of recurrence or metastasis were observed. CONCLUSIONS: In head and neck cutaneous SCC, the invasion depth of the tumor is closely related to the major and minor axis lengths of the tumor. Therefore, the invasion depth of the tumor can be estimated by measuring the size of the tumor, and a standard vertical safety margin for head and neck cutaneous SCC can be established, which could be helpful in the development of a preoperative reconstruction plan. The Korean Society of Plastic and Reconstructive Surgeons 2016-11 2016-11-18 /pmc/articles/PMC5122543/ /pubmed/27896185 http://dx.doi.org/10.5999/aps.2016.43.6.538 Text en Copyright © 2016 The Korean Society of Plastic and Reconstructive Surgeons http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Lee, Sam Yong
Hwang, Won Joo
Kim, Kyung Pil
Kim, Hong Min
Hwang, Jae Ha
Kim, Kwang Seog
The Relationship between the Size and the Invasion Depth of Tumors in Head and Neck Cutaneous Squamous Cell Carcinoma
title The Relationship between the Size and the Invasion Depth of Tumors in Head and Neck Cutaneous Squamous Cell Carcinoma
title_full The Relationship between the Size and the Invasion Depth of Tumors in Head and Neck Cutaneous Squamous Cell Carcinoma
title_fullStr The Relationship between the Size and the Invasion Depth of Tumors in Head and Neck Cutaneous Squamous Cell Carcinoma
title_full_unstemmed The Relationship between the Size and the Invasion Depth of Tumors in Head and Neck Cutaneous Squamous Cell Carcinoma
title_short The Relationship between the Size and the Invasion Depth of Tumors in Head and Neck Cutaneous Squamous Cell Carcinoma
title_sort relationship between the size and the invasion depth of tumors in head and neck cutaneous squamous cell carcinoma
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5122543/
https://www.ncbi.nlm.nih.gov/pubmed/27896185
http://dx.doi.org/10.5999/aps.2016.43.6.538
work_keys_str_mv AT leesamyong therelationshipbetweenthesizeandtheinvasiondepthoftumorsinheadandneckcutaneoussquamouscellcarcinoma
AT hwangwonjoo therelationshipbetweenthesizeandtheinvasiondepthoftumorsinheadandneckcutaneoussquamouscellcarcinoma
AT kimkyungpil therelationshipbetweenthesizeandtheinvasiondepthoftumorsinheadandneckcutaneoussquamouscellcarcinoma
AT kimhongmin therelationshipbetweenthesizeandtheinvasiondepthoftumorsinheadandneckcutaneoussquamouscellcarcinoma
AT hwangjaeha therelationshipbetweenthesizeandtheinvasiondepthoftumorsinheadandneckcutaneoussquamouscellcarcinoma
AT kimkwangseog therelationshipbetweenthesizeandtheinvasiondepthoftumorsinheadandneckcutaneoussquamouscellcarcinoma
AT leesamyong relationshipbetweenthesizeandtheinvasiondepthoftumorsinheadandneckcutaneoussquamouscellcarcinoma
AT hwangwonjoo relationshipbetweenthesizeandtheinvasiondepthoftumorsinheadandneckcutaneoussquamouscellcarcinoma
AT kimkyungpil relationshipbetweenthesizeandtheinvasiondepthoftumorsinheadandneckcutaneoussquamouscellcarcinoma
AT kimhongmin relationshipbetweenthesizeandtheinvasiondepthoftumorsinheadandneckcutaneoussquamouscellcarcinoma
AT hwangjaeha relationshipbetweenthesizeandtheinvasiondepthoftumorsinheadandneckcutaneoussquamouscellcarcinoma
AT kimkwangseog relationshipbetweenthesizeandtheinvasiondepthoftumorsinheadandneckcutaneoussquamouscellcarcinoma