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Association between Leukocyte Mitochondrial DNA Copy Number and Regular Exercise in Postmenopausal Women
BACKGROUND: Previous studies suggest that habitual exercise can improve skeletal mitochondrial function; however, to date, the association between exercise and mitochondrial function in peripheral leukocytes has not been reported. The aim of this study was to evaluate the relationship between regula...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Korean Academy of Family Medicine
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5122665/ https://www.ncbi.nlm.nih.gov/pubmed/27900071 http://dx.doi.org/10.4082/kjfm.2016.37.6.334 |
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author | Chang, Yu Kyung Kim, Da Eun Cho, Soo Hyun Kim, Jung-Ha |
author_facet | Chang, Yu Kyung Kim, Da Eun Cho, Soo Hyun Kim, Jung-Ha |
author_sort | Chang, Yu Kyung |
collection | PubMed |
description | BACKGROUND: Previous studies suggest that habitual exercise can improve skeletal mitochondrial function; however, to date, the association between exercise and mitochondrial function in peripheral leukocytes has not been reported. The aim of this study was to evaluate the relationship between regular exercise and mitochondrial function by measuring leukocyte mitochondrial DNA (mtDNA) copy number in postmenopausal women. METHODS: This cross-sectional study included 144 relatively healthy, non-diabetic, non-smoking, postmenopausal women. Clinical parameters, including anthropometric measurements and cardio-metabolic parameters, were assessed. Regular exercise was defined as at least 150 minutes per week of moderate-intensity activity, or an equivalent combination of moderate and vigorous-intensity activity, over a duration of at least 6 months. Leukocyte mtDNA copy numbers were measured using real-time polymerase chain reaction assays, and these were normalized to the β-globin copy number to give the relative mtDNA copy number. RESULTS: The mtDNA copy number of peripheral leukocytes was significantly greater in the exercise group (1.33±0.02) than in the no exercise group (1.05±0.02, P<0.01). Stepwise multiple regression analysis showed that regular exercise was independently associated with mtDNA copy number (β=0.25, P<0.01) after adjusting for the variables age, body mass index, waist-to-hip ratio, systolic and diastolic blood pressure, homeostasis model assessment of insulin resistance value, and levels of high-density lipoprotein cholesterol, triglycerides, and homocysteine. CONCLUSION: Regular exercise is associated with greater leukocyte mtDNA copy number in postmenopausal women. |
format | Online Article Text |
id | pubmed-5122665 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | The Korean Academy of Family Medicine |
record_format | MEDLINE/PubMed |
spelling | pubmed-51226652016-11-29 Association between Leukocyte Mitochondrial DNA Copy Number and Regular Exercise in Postmenopausal Women Chang, Yu Kyung Kim, Da Eun Cho, Soo Hyun Kim, Jung-Ha Korean J Fam Med Original Article BACKGROUND: Previous studies suggest that habitual exercise can improve skeletal mitochondrial function; however, to date, the association between exercise and mitochondrial function in peripheral leukocytes has not been reported. The aim of this study was to evaluate the relationship between regular exercise and mitochondrial function by measuring leukocyte mitochondrial DNA (mtDNA) copy number in postmenopausal women. METHODS: This cross-sectional study included 144 relatively healthy, non-diabetic, non-smoking, postmenopausal women. Clinical parameters, including anthropometric measurements and cardio-metabolic parameters, were assessed. Regular exercise was defined as at least 150 minutes per week of moderate-intensity activity, or an equivalent combination of moderate and vigorous-intensity activity, over a duration of at least 6 months. Leukocyte mtDNA copy numbers were measured using real-time polymerase chain reaction assays, and these were normalized to the β-globin copy number to give the relative mtDNA copy number. RESULTS: The mtDNA copy number of peripheral leukocytes was significantly greater in the exercise group (1.33±0.02) than in the no exercise group (1.05±0.02, P<0.01). Stepwise multiple regression analysis showed that regular exercise was independently associated with mtDNA copy number (β=0.25, P<0.01) after adjusting for the variables age, body mass index, waist-to-hip ratio, systolic and diastolic blood pressure, homeostasis model assessment of insulin resistance value, and levels of high-density lipoprotein cholesterol, triglycerides, and homocysteine. CONCLUSION: Regular exercise is associated with greater leukocyte mtDNA copy number in postmenopausal women. The Korean Academy of Family Medicine 2016-11 2016-11-18 /pmc/articles/PMC5122665/ /pubmed/27900071 http://dx.doi.org/10.4082/kjfm.2016.37.6.334 Text en Copyright © 2016 The Korean Academy of Family Medicine http://creativecommons.org/licenses/by-nc/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Chang, Yu Kyung Kim, Da Eun Cho, Soo Hyun Kim, Jung-Ha Association between Leukocyte Mitochondrial DNA Copy Number and Regular Exercise in Postmenopausal Women |
title | Association between Leukocyte Mitochondrial DNA Copy Number and Regular Exercise in Postmenopausal Women |
title_full | Association between Leukocyte Mitochondrial DNA Copy Number and Regular Exercise in Postmenopausal Women |
title_fullStr | Association between Leukocyte Mitochondrial DNA Copy Number and Regular Exercise in Postmenopausal Women |
title_full_unstemmed | Association between Leukocyte Mitochondrial DNA Copy Number and Regular Exercise in Postmenopausal Women |
title_short | Association between Leukocyte Mitochondrial DNA Copy Number and Regular Exercise in Postmenopausal Women |
title_sort | association between leukocyte mitochondrial dna copy number and regular exercise in postmenopausal women |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5122665/ https://www.ncbi.nlm.nih.gov/pubmed/27900071 http://dx.doi.org/10.4082/kjfm.2016.37.6.334 |
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