Dataset of botulinum toxin A influence on interleukins under neuropathy

Our data show that botulinum toxin A (BoNT/A) didn’t influence motor functions in naïve and CCI-exposed rats, but diminished the neuropathic pain-related behavior. The results indicate that BoNT/A administration diminished the spinal Iba-1 positive cells activation and, in parallel, downregulated IL...

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Autores principales: Zychowska, Magdalena, Rojewska, Ewelina, Makuch, Wioletta, Luvisetto, Siro, Pavone, Flaminia, Marinelli, Sara, Przewlocka, Barbara, Mika, Joanna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2016
Materias:
Data Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5122696/
https://www.ncbi.nlm.nih.gov/pubmed/27900354
http://dx.doi.org/10.1016/j.dib.2016.11.023
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author Zychowska, Magdalena
Rojewska, Ewelina
Makuch, Wioletta
Luvisetto, Siro
Pavone, Flaminia
Marinelli, Sara
Przewlocka, Barbara
Mika, Joanna
author_facet Zychowska, Magdalena
Rojewska, Ewelina
Makuch, Wioletta
Luvisetto, Siro
Pavone, Flaminia
Marinelli, Sara
Przewlocka, Barbara
Mika, Joanna
author_sort Zychowska, Magdalena
collection PubMed
description Our data show that botulinum toxin A (BoNT/A) didn’t influence motor functions in naïve and CCI-exposed rats, but diminished the neuropathic pain-related behavior. The results indicate that BoNT/A administration diminished the spinal Iba-1 positive cells activation and, in parallel, downregulated IL-1beta. Moreover, we observed that in DRG the protein level of pronociceptive factors (IL-1beta and IL-18) decreased and antinociceptive (IL-10 and IL-1RA) factors increased. Additionally, our behavioral analysis shows that chronic minocycline treatment together with a single BoNT/A injection in CCI-exposed rats has beneficial analgesic effects (M. Zychowska, E. Rojewska, W. Makuch, S. Luvisetto, F. Pavone, S. Marinelli, B. Przewlocka, J. Mika, 2016) [1].
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spelling pubmed-51226962016-11-29 Dataset of botulinum toxin A influence on interleukins under neuropathy Zychowska, Magdalena Rojewska, Ewelina Makuch, Wioletta Luvisetto, Siro Pavone, Flaminia Marinelli, Sara Przewlocka, Barbara Mika, Joanna Data Brief Data Article Our data show that botulinum toxin A (BoNT/A) didn’t influence motor functions in naïve and CCI-exposed rats, but diminished the neuropathic pain-related behavior. The results indicate that BoNT/A administration diminished the spinal Iba-1 positive cells activation and, in parallel, downregulated IL-1beta. Moreover, we observed that in DRG the protein level of pronociceptive factors (IL-1beta and IL-18) decreased and antinociceptive (IL-10 and IL-1RA) factors increased. Additionally, our behavioral analysis shows that chronic minocycline treatment together with a single BoNT/A injection in CCI-exposed rats has beneficial analgesic effects (M. Zychowska, E. Rojewska, W. Makuch, S. Luvisetto, F. Pavone, S. Marinelli, B. Przewlocka, J. Mika, 2016) [1]. Elsevier 2016-11-15 /pmc/articles/PMC5122696/ /pubmed/27900354 http://dx.doi.org/10.1016/j.dib.2016.11.023 Text en © 2016 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Data Article
Zychowska, Magdalena
Rojewska, Ewelina
Makuch, Wioletta
Luvisetto, Siro
Pavone, Flaminia
Marinelli, Sara
Przewlocka, Barbara
Mika, Joanna
Dataset of botulinum toxin A influence on interleukins under neuropathy
title Dataset of botulinum toxin A influence on interleukins under neuropathy
title_full Dataset of botulinum toxin A influence on interleukins under neuropathy
title_fullStr Dataset of botulinum toxin A influence on interleukins under neuropathy
title_full_unstemmed Dataset of botulinum toxin A influence on interleukins under neuropathy
title_short Dataset of botulinum toxin A influence on interleukins under neuropathy
title_sort dataset of botulinum toxin a influence on interleukins under neuropathy
topic Data Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5122696/
https://www.ncbi.nlm.nih.gov/pubmed/27900354
http://dx.doi.org/10.1016/j.dib.2016.11.023
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