Mevalonate kinase deficiency leads to decreased prenylation of Rab GTPases

Mevalonate kinase deficiency (MKD) is caused by mutations in a key enzyme of the mevalonate–cholesterol biosynthesis pathway, leading to recurrent autoinflammatory disease characterised by enhanced release of interleukin-1β (IL-1β). It is currently believed that the inflammatory phenotype of MKD is...

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Detalles Bibliográficos
Autores principales: Jurczyluk, Julie, Munoz, Marcia A, Skinner, Oliver P, Chai, Ryan C, Ali, Naveid, Palendira, Umaimainthan, Quinn, Julian MW, Preston, Alexandra, Tangye, Stuart G, Brown, Andrew J, Argent, Elizabeth, Ziegler, John B, Mehr, Sam, Rogers, Michael J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5122740/
https://www.ncbi.nlm.nih.gov/pubmed/27377765
http://dx.doi.org/10.1038/icb.2016.58

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