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Homodimerization of the Lymph Vessel Endothelial Receptor LYVE-1 through a Redox-labile Disulfide Is Critical for Hyaluronan Binding in Lymphatic Endothelium
The lymphatic vessel endothelial receptor LYVE-1 is implicated in the uptake of hyaluronan (HA) and trafficking of leukocytes to draining lymph nodes. Yet LYVE-1 has only weak affinity for hyaluronan and depends on receptor clustering and higher order ligand organization for durable binding in lymph...
Autores principales: | Banerji, Suneale, Lawrance, William, Metcalfe, Clive, Briggs, David C., Yamauchi, Akira, Dushek, Omer, van der Merwe, P. Anton, Day, Anthony J., Jackson, David G. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society for Biochemistry and Molecular Biology
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5122770/ https://www.ncbi.nlm.nih.gov/pubmed/27733683 http://dx.doi.org/10.1074/jbc.M116.736926 |
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