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Epigenetic mechanisms drive the progression of neurofibromas to malignant peripheral nerve sheath tumors

THINKING OUTSIDE THE BOX: The polycomb repressive complex 2 (PRC2) is a histone methyltransferase complex known to repress gene expression. There is a large body of experimental evidence that supports its role in promoting tumorigenicity by suppressing tumor suppressor genes. Here, we discuss the su...

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Detalles Bibliográficos
Autores principales:	Suresh, Krish, Kliot, Tamara, Piunti, Andrea, Kliot, Michel
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Medknow Publications & Media Pvt Ltd 2016
Materias:	Review Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5122817/ https://www.ncbi.nlm.nih.gov/pubmed/27920939 http://dx.doi.org/10.4103/2152-7806.194058

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