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Pharmacological characterization of liquiritigenin, a chiral flavonoid in licorice

Liquiritigenin is a chiral flavonoid present in plant based food, nutraceuticals, and traditional medicines. It is also an important ingredient present in licorice. The purpose of this study is to explore the pharmacological activity of racemic liquiritigenin utilizing several in vitro assays with r...

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Autores principales: Alrushaid, Samaa, Davies, Neal M., Martinez, Stephanie E., Sayre, Casey L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5122824/
https://www.ncbi.nlm.nih.gov/pubmed/27920817
http://dx.doi.org/10.4103/1735-5362.192484
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author Alrushaid, Samaa
Davies, Neal M.
Martinez, Stephanie E.
Sayre, Casey L.
author_facet Alrushaid, Samaa
Davies, Neal M.
Martinez, Stephanie E.
Sayre, Casey L.
author_sort Alrushaid, Samaa
collection PubMed
description Liquiritigenin is a chiral flavonoid present in plant based food, nutraceuticals, and traditional medicines. It is also an important ingredient present in licorice. The purpose of this study is to explore the pharmacological activity of racemic liquiritigenin utilizing several in vitro assays with relevant roles in colon cancer and diabetes. Where possible, the pure enantiomers were tested to identify the stereospecific contribution to the activity. In vitro antioxidant, anticancer, anti-inflammatory activities (cyclooxygenase inhibition), antidiabetic activities (alpha-amylase and alpha-glucosidase inhibition) as well as cytochrome P450 (CYP450) inhibitory activities were assessed. Racemic liquiritigenin demonstrated a dose-dependent inhibition of alpha-amylase enzyme whereas its pure enantiomers did not. Racemic liquiritigenin showed moderate antiproliferative activity on a HT-29 (human colorectal adenocarcinoma) cancer cell line that was dose-dependent and potent inhibitory effects on the cyclooxygenase-2 enzyme. The flavonoid did not inhibit the activity of cytochrome CYP2D6 over the concentration range studied but was a potent antioxidant. The current study demonstrated the importance of understanding the stereospecific pharmacological effects of liquiritigenin enantiomers in alpha-amylase inhibition.
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spelling pubmed-51228242016-12-05 Pharmacological characterization of liquiritigenin, a chiral flavonoid in licorice Alrushaid, Samaa Davies, Neal M. Martinez, Stephanie E. Sayre, Casey L. Res Pharm Sci Original Article Liquiritigenin is a chiral flavonoid present in plant based food, nutraceuticals, and traditional medicines. It is also an important ingredient present in licorice. The purpose of this study is to explore the pharmacological activity of racemic liquiritigenin utilizing several in vitro assays with relevant roles in colon cancer and diabetes. Where possible, the pure enantiomers were tested to identify the stereospecific contribution to the activity. In vitro antioxidant, anticancer, anti-inflammatory activities (cyclooxygenase inhibition), antidiabetic activities (alpha-amylase and alpha-glucosidase inhibition) as well as cytochrome P450 (CYP450) inhibitory activities were assessed. Racemic liquiritigenin demonstrated a dose-dependent inhibition of alpha-amylase enzyme whereas its pure enantiomers did not. Racemic liquiritigenin showed moderate antiproliferative activity on a HT-29 (human colorectal adenocarcinoma) cancer cell line that was dose-dependent and potent inhibitory effects on the cyclooxygenase-2 enzyme. The flavonoid did not inhibit the activity of cytochrome CYP2D6 over the concentration range studied but was a potent antioxidant. The current study demonstrated the importance of understanding the stereospecific pharmacological effects of liquiritigenin enantiomers in alpha-amylase inhibition. Medknow Publications & Media Pvt Ltd 2016-10 /pmc/articles/PMC5122824/ /pubmed/27920817 http://dx.doi.org/10.4103/1735-5362.192484 Text en Copyright: © Research in Pharmaceutical Sciences http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.
spellingShingle Original Article
Alrushaid, Samaa
Davies, Neal M.
Martinez, Stephanie E.
Sayre, Casey L.
Pharmacological characterization of liquiritigenin, a chiral flavonoid in licorice
title Pharmacological characterization of liquiritigenin, a chiral flavonoid in licorice
title_full Pharmacological characterization of liquiritigenin, a chiral flavonoid in licorice
title_fullStr Pharmacological characterization of liquiritigenin, a chiral flavonoid in licorice
title_full_unstemmed Pharmacological characterization of liquiritigenin, a chiral flavonoid in licorice
title_short Pharmacological characterization of liquiritigenin, a chiral flavonoid in licorice
title_sort pharmacological characterization of liquiritigenin, a chiral flavonoid in licorice
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5122824/
https://www.ncbi.nlm.nih.gov/pubmed/27920817
http://dx.doi.org/10.4103/1735-5362.192484
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