CXCR4/CXCL12 axis counteracts hematopoietic stem cell exhaustion through selective protection against oxidative stress

Hematopoietic stem cells (HSCs) undergo self-renewal to maintain hematopoietic homeostasis for lifetime, which is regulated by the bone marrow (BM) microenvironment. The chemokine receptor CXCR4 and its ligand CXCL12 are critical factors supporting quiescence and BM retention of HSCs. Here, we repor...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhang, Yanyan, Dépond, Mallorie, He, Liang, Foudi, Adlen, Kwarteng, Edward Owusu, Lauret, Evelyne, Plo, Isabelle, Desterke, Christophe, Dessen, Philippe, Fujii, Nobutaka, Opolon, Paule, Herault, Olivier, Solary, Eric, Vainchenker, William, Joulin, Virginie, Louache, Fawzia, Wittner, Monika
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5122894/
https://www.ncbi.nlm.nih.gov/pubmed/27886253
http://dx.doi.org/10.1038/srep37827

Ejemplares similares

Ejemplares similares