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Family-based clusters of cognitive test performance in familial schizophrenia

BACKGROUND: Cognitive traits derived from neuropsychological test data are considered to be potential endophenotypes of schizophrenia. Previously, these traits have been found to form a valid basis for clustering samples of schizophrenia patients into homogeneous subgroups. We set out to identify su...

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Autores principales: Hoti, Fabian, Tuulio-Henriksson, Annamari, Haukka, Jari, Partonen, Timo, Holmström, Lasse, Lönnqvist, Jouko
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2004
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC512293/
https://www.ncbi.nlm.nih.gov/pubmed/15271222
http://dx.doi.org/10.1186/1471-244X-4-20
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author Hoti, Fabian
Tuulio-Henriksson, Annamari
Haukka, Jari
Partonen, Timo
Holmström, Lasse
Lönnqvist, Jouko
author_facet Hoti, Fabian
Tuulio-Henriksson, Annamari
Haukka, Jari
Partonen, Timo
Holmström, Lasse
Lönnqvist, Jouko
author_sort Hoti, Fabian
collection PubMed
description BACKGROUND: Cognitive traits derived from neuropsychological test data are considered to be potential endophenotypes of schizophrenia. Previously, these traits have been found to form a valid basis for clustering samples of schizophrenia patients into homogeneous subgroups. We set out to identify such clusters, but apart from previous studies, we included both schizophrenia patients and family members into the cluster analysis. The aim of the study was to detect family clusters with similar cognitive test performance. METHODS: Test scores from 54 randomly selected families comprising at least two siblings with schizophrenia spectrum disorders, and at least two unaffected family members were included in a complete-linkage cluster analysis with interactive data visualization. RESULTS: A well-performing, an impaired, and an intermediate family cluster emerged from the analysis. While the neuropsychological test scores differed significantly between the clusters, only minor differences were observed in the clinical variables. CONCLUSIONS: The visually aided clustering algorithm was successful in identifying family clusters comprising both schizophrenia patients and their relatives. The present classification method may serve as a basis for selecting phenotypically more homogeneous groups of families in subsequent genetic analyses.
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spelling pubmed-5122932004-08-19 Family-based clusters of cognitive test performance in familial schizophrenia Hoti, Fabian Tuulio-Henriksson, Annamari Haukka, Jari Partonen, Timo Holmström, Lasse Lönnqvist, Jouko BMC Psychiatry Research Article BACKGROUND: Cognitive traits derived from neuropsychological test data are considered to be potential endophenotypes of schizophrenia. Previously, these traits have been found to form a valid basis for clustering samples of schizophrenia patients into homogeneous subgroups. We set out to identify such clusters, but apart from previous studies, we included both schizophrenia patients and family members into the cluster analysis. The aim of the study was to detect family clusters with similar cognitive test performance. METHODS: Test scores from 54 randomly selected families comprising at least two siblings with schizophrenia spectrum disorders, and at least two unaffected family members were included in a complete-linkage cluster analysis with interactive data visualization. RESULTS: A well-performing, an impaired, and an intermediate family cluster emerged from the analysis. While the neuropsychological test scores differed significantly between the clusters, only minor differences were observed in the clinical variables. CONCLUSIONS: The visually aided clustering algorithm was successful in identifying family clusters comprising both schizophrenia patients and their relatives. The present classification method may serve as a basis for selecting phenotypically more homogeneous groups of families in subsequent genetic analyses. BioMed Central 2004-07-22 /pmc/articles/PMC512293/ /pubmed/15271222 http://dx.doi.org/10.1186/1471-244X-4-20 Text en Copyright © 2004 Hoti et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an open-access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Hoti, Fabian
Tuulio-Henriksson, Annamari
Haukka, Jari
Partonen, Timo
Holmström, Lasse
Lönnqvist, Jouko
Family-based clusters of cognitive test performance in familial schizophrenia
title Family-based clusters of cognitive test performance in familial schizophrenia
title_full Family-based clusters of cognitive test performance in familial schizophrenia
title_fullStr Family-based clusters of cognitive test performance in familial schizophrenia
title_full_unstemmed Family-based clusters of cognitive test performance in familial schizophrenia
title_short Family-based clusters of cognitive test performance in familial schizophrenia
title_sort family-based clusters of cognitive test performance in familial schizophrenia
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC512293/
https://www.ncbi.nlm.nih.gov/pubmed/15271222
http://dx.doi.org/10.1186/1471-244X-4-20
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