IRS4 induces mammary tumorigenesis and confers resistance to HER2-targeted therapy through constitutive PI3K/AKT-pathway hyperactivation

In search of oncogenic drivers and mechanisms affecting therapy resistance in breast cancer, we identified Irs4, a poorly studied member of the insulin receptor substrate (IRS) family, as a mammary oncogene by insertional mutagenesis. Whereas normally silent in the postnatal mammary gland, IRS4 is f...

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Detalles Bibliográficos
Autores principales: Ikink, Gerjon J., Boer, Mandy, Bakker, Elvira R. M., Hilkens, John
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5122961/
https://www.ncbi.nlm.nih.gov/pubmed/27876799
http://dx.doi.org/10.1038/ncomms13567

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5122961/
https://www.ncbi.nlm.nih.gov/pubmed/27876799
http://dx.doi.org/10.1038/ncomms13567

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