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Plasma glutamine levels before cardiac surgery are related to post-surgery infections; an observational study
BACKGROUND: A low plasma glutamine level was found in 34% of patients after elective cardiothoracic surgery. This could be a result of the inflammation caused by surgical stress or the use of extracorporeal circulation (ECC). But it is also possible that plasma glutamine levels were already lowered...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5123213/ https://www.ncbi.nlm.nih.gov/pubmed/27884211 http://dx.doi.org/10.1186/s13019-016-0549-1 |
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author | Buter, Hanneke Koopmans, Matty Kemperman, Ramses Jekel, Lilian Boerma, Christiaan |
author_facet | Buter, Hanneke Koopmans, Matty Kemperman, Ramses Jekel, Lilian Boerma, Christiaan |
author_sort | Buter, Hanneke |
collection | PubMed |
description | BACKGROUND: A low plasma glutamine level was found in 34% of patients after elective cardiothoracic surgery. This could be a result of the inflammation caused by surgical stress or the use of extracorporeal circulation (ECC). But it is also possible that plasma glutamine levels were already lowered before surgery and reflect an impaired metabolic state and a higher likelihood to develop complications. In the present study plasma glutamine levels were measured before and after cardiac surgery and we questioned whether there is a relation between plasma glutamine levels and duration of ECC and the occurrence of postoperative infections. METHODS: We performed a single-centre prospective, observational study in a closed-format, 20-bed, mixed ICU in a tertiary teaching hospital. We included consecutive patients after elective cardiac surgery with use of extracorporeal circulation. Blood samples were collected on the day prior to surgery and at admission on the ICU. The study was approved by the local Medical Ethics Committee (Regional Review Committee Patient-related Research, Medical Centre Leeuwarden, nWMO 115, April 28th 2015). RESULTS: Ninety patients were included. Pre-operative plasma glutamine level was 0.42 ± 0.10 mmol/l and post-operative 0.38 ± 0.09 mmol/l (p < 0.001). There was no relation between duration of extracorporeal circulation or aortic occlusion time and changes in plasma glutamine levels. A logistic regression analysis showed a significant correlation between the presence of a positive culture during the post-operative course and pre-operative plasma glutamine levels (p = 0.04). CONCLUSION: Plasma glutamine levels are significantly lower just after cardiac surgery compared to pre-operative levels. We did not find a relation between the decrease in plasma glutamine levels and the duration of extracorporeal circulation or aortic clamp time. There was a correlation between pre-operative plasma glutamine levels and the presence of a positive culture after cardiac surgery. TRIAL REGISTRATION: ClinicalTrials.gov, number NCT02444780. |
format | Online Article Text |
id | pubmed-5123213 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-51232132016-12-06 Plasma glutamine levels before cardiac surgery are related to post-surgery infections; an observational study Buter, Hanneke Koopmans, Matty Kemperman, Ramses Jekel, Lilian Boerma, Christiaan J Cardiothorac Surg Research Article BACKGROUND: A low plasma glutamine level was found in 34% of patients after elective cardiothoracic surgery. This could be a result of the inflammation caused by surgical stress or the use of extracorporeal circulation (ECC). But it is also possible that plasma glutamine levels were already lowered before surgery and reflect an impaired metabolic state and a higher likelihood to develop complications. In the present study plasma glutamine levels were measured before and after cardiac surgery and we questioned whether there is a relation between plasma glutamine levels and duration of ECC and the occurrence of postoperative infections. METHODS: We performed a single-centre prospective, observational study in a closed-format, 20-bed, mixed ICU in a tertiary teaching hospital. We included consecutive patients after elective cardiac surgery with use of extracorporeal circulation. Blood samples were collected on the day prior to surgery and at admission on the ICU. The study was approved by the local Medical Ethics Committee (Regional Review Committee Patient-related Research, Medical Centre Leeuwarden, nWMO 115, April 28th 2015). RESULTS: Ninety patients were included. Pre-operative plasma glutamine level was 0.42 ± 0.10 mmol/l and post-operative 0.38 ± 0.09 mmol/l (p < 0.001). There was no relation between duration of extracorporeal circulation or aortic occlusion time and changes in plasma glutamine levels. A logistic regression analysis showed a significant correlation between the presence of a positive culture during the post-operative course and pre-operative plasma glutamine levels (p = 0.04). CONCLUSION: Plasma glutamine levels are significantly lower just after cardiac surgery compared to pre-operative levels. We did not find a relation between the decrease in plasma glutamine levels and the duration of extracorporeal circulation or aortic clamp time. There was a correlation between pre-operative plasma glutamine levels and the presence of a positive culture after cardiac surgery. TRIAL REGISTRATION: ClinicalTrials.gov, number NCT02444780. BioMed Central 2016-11-25 /pmc/articles/PMC5123213/ /pubmed/27884211 http://dx.doi.org/10.1186/s13019-016-0549-1 Text en © The Author(s). 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Article Buter, Hanneke Koopmans, Matty Kemperman, Ramses Jekel, Lilian Boerma, Christiaan Plasma glutamine levels before cardiac surgery are related to post-surgery infections; an observational study |
title | Plasma glutamine levels before cardiac surgery are related to post-surgery infections; an observational study |
title_full | Plasma glutamine levels before cardiac surgery are related to post-surgery infections; an observational study |
title_fullStr | Plasma glutamine levels before cardiac surgery are related to post-surgery infections; an observational study |
title_full_unstemmed | Plasma glutamine levels before cardiac surgery are related to post-surgery infections; an observational study |
title_short | Plasma glutamine levels before cardiac surgery are related to post-surgery infections; an observational study |
title_sort | plasma glutamine levels before cardiac surgery are related to post-surgery infections; an observational study |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5123213/ https://www.ncbi.nlm.nih.gov/pubmed/27884211 http://dx.doi.org/10.1186/s13019-016-0549-1 |
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