Large-scale benchmarking reveals false discoveries and count transformation sensitivity in 16S rRNA gene amplicon data analysis methods used in microbiome studies

BACKGROUND: There is an immense scientific interest in the human microbiome and its effects on human physiology, health, and disease. A common approach for examining bacterial communities is high-throughput sequencing of 16S rRNA gene hypervariable regions, aggregating sequence-similar amplicons int...

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Detalles Bibliográficos
Autores principales: Thorsen, Jonathan, Brejnrod, Asker, Mortensen, Martin, Rasmussen, Morten A., Stokholm, Jakob, Al-Soud, Waleed Abu, Sørensen, Søren, Bisgaard, Hans, Waage, Johannes
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Methodology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5123278/
https://www.ncbi.nlm.nih.gov/pubmed/27884206
http://dx.doi.org/10.1186/s40168-016-0208-8

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