The D Domain of LRRC4 anchors ERK1/2 in the cytoplasm and competitively inhibits MEK/ERK activation in glioma cells

BACKGROUND: As a well-characterized key player in various signal transduction networks, extracellular-signal-regulated kinase (ERK1/2) has been widely implicated in the development of many malignancies. We previously found that Leucine-rich repeat containing 4 (LRRC4) was a tumor suppressor and a ne...

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Detalles Bibliográficos
Autores principales: Wang, Zeyou, Guo, Qin, Wang, Rong, Xu, Gang, Li, Peiyao, Sun, Yingnan, She, Xiaoling, Liu, Qiang, Chen, Qiong, Yu, Zhibin, Liu, Changhong, Xiong, Jing, Li, Guiyuan, Wu, Minghua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5123285/
https://www.ncbi.nlm.nih.gov/pubmed/27884160
http://dx.doi.org/10.1186/s13045-016-0355-1

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