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Chronic adiponectin deficiency leads to Alzheimer’s disease-like cognitive impairments and pathologies through AMPK inactivation and cerebral insulin resistance in aged mice

BACKGROUND: Insulin resistance is the major pathogenesis underlying type 2 diabetes mellitus (T2DM) and these patients have doubled risk of Alzheimer’s disease (AD). Increasing evidence suggests that insulin resistance plays an important role in AD pathogenesis, possibly due to abnormal GSK3β activa...

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Detalles Bibliográficos
Autores principales:	Ng, Roy Chun-Laam, Cheng, On-Yin, Jian, Min, Kwan, Jason Shing-Cheong, Ho, Philip Wing-Lok, Cheng, Kenneth King-Yip, Yeung, Patrick Ka Kit, Zhou, Lena Lei, Hoo, Ruby Lai-Chong, Chung, Sookja Kim, Xu, Aimin, Lam, Karen Siu-Ling., Chan, Koon Ho
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5123368/ https://www.ncbi.nlm.nih.gov/pubmed/27884163 http://dx.doi.org/10.1186/s13024-016-0136-x

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