Chronic oxidative stress promotes H2AX protein degradation and enhances chemosensitivity in breast cancer patients

Anti‐cancer drugs often increase reactive oxygen species (ROS) and cause DNA damage. Here, we highlight a new cross talk between chronic oxidative stress and the histone variant H2AX, a key player in DNA repair. We observe that persistent accumulation of ROS, due to a deficient JunD‐/Nrf2‐antioxidan...

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Detalles Bibliográficos
Autores principales: Gruosso, Tina, Mieulet, Virginie, Cardon, Melissa, Bourachot, Brigitte, Kieffer, Yann, Devun, Flavien, Dubois, Thierry, Dutreix, Marie, Vincent‐Salomon, Anne, Miller, Kyle Malcolm, Mechta‐Grigoriou, Fatima
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5123617/
https://www.ncbi.nlm.nih.gov/pubmed/27006338
http://dx.doi.org/10.15252/emmm.201505891

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