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Collagen: a network for regenerative medicine
The basic building block of the extra-cellular matrix in native tissue is collagen. As a structural protein, collagen has an inherent biocompatibility making it an ideal material for regenerative medicine. Cellular response, mediated by integrins, is dictated by the structure and chemistry of the co...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Royal Society of Chemistry
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5123637/ https://www.ncbi.nlm.nih.gov/pubmed/27928505 http://dx.doi.org/10.1039/c6tb00807k |
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author | Pawelec, K. M. Best, S. M. Cameron, R. E. |
author_facet | Pawelec, K. M. Best, S. M. Cameron, R. E. |
author_sort | Pawelec, K. M. |
collection | PubMed |
description | The basic building block of the extra-cellular matrix in native tissue is collagen. As a structural protein, collagen has an inherent biocompatibility making it an ideal material for regenerative medicine. Cellular response, mediated by integrins, is dictated by the structure and chemistry of the collagen fibers. Fiber formation, via fibrillogenesis, can be controlled in vitro by several factors: pH, ionic strength, and collagen structure. After formation, fibers are stabilized via cross-linking. The final bioactivity of collagen scaffolds is a result of both processes. By considering each step of fabrication, scaffolds can be tailored for the specific needs of each tissue, improving their therapeutic potential. |
format | Online Article Text |
id | pubmed-5123637 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Royal Society of Chemistry |
record_format | MEDLINE/PubMed |
spelling | pubmed-51236372016-12-05 Collagen: a network for regenerative medicine Pawelec, K. M. Best, S. M. Cameron, R. E. J Mater Chem B Mater Biol Med Chemistry The basic building block of the extra-cellular matrix in native tissue is collagen. As a structural protein, collagen has an inherent biocompatibility making it an ideal material for regenerative medicine. Cellular response, mediated by integrins, is dictated by the structure and chemistry of the collagen fibers. Fiber formation, via fibrillogenesis, can be controlled in vitro by several factors: pH, ionic strength, and collagen structure. After formation, fibers are stabilized via cross-linking. The final bioactivity of collagen scaffolds is a result of both processes. By considering each step of fabrication, scaffolds can be tailored for the specific needs of each tissue, improving their therapeutic potential. Royal Society of Chemistry 2016-10-28 2016-08-22 /pmc/articles/PMC5123637/ /pubmed/27928505 http://dx.doi.org/10.1039/c6tb00807k Text en This journal is © The Royal Society of Chemistry 2016 http://creativecommons.org/licenses/by/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution 3.0 Unported License (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Chemistry Pawelec, K. M. Best, S. M. Cameron, R. E. Collagen: a network for regenerative medicine |
title | Collagen: a network for regenerative medicine |
title_full | Collagen: a network for regenerative medicine |
title_fullStr | Collagen: a network for regenerative medicine |
title_full_unstemmed | Collagen: a network for regenerative medicine |
title_short | Collagen: a network for regenerative medicine |
title_sort | collagen: a network for regenerative medicine |
topic | Chemistry |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5123637/ https://www.ncbi.nlm.nih.gov/pubmed/27928505 http://dx.doi.org/10.1039/c6tb00807k |
work_keys_str_mv | AT paweleckm collagenanetworkforregenerativemedicine AT bestsm collagenanetworkforregenerativemedicine AT cameronre collagenanetworkforregenerativemedicine |