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Suzuki–Miyaura cross-coupling optimization enabled by automated feedback

An automated, droplet-flow microfluidic system explores and optimizes Pd-catalyzed Suzuki–Miyaura cross-coupling reactions. A smart optimal DoE-based algorithm is implemented to increase the turnover number and yield of the catalytic system considering both discrete variables—palladacycle and ligand...

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Detalles Bibliográficos
Autores principales:	Reizman, Brandon J., Wang, Yi-Ming, Buchwald, Stephen L., Jensen, Klavs F.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Royal Society of Chemistry 2016
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5123644/ https://www.ncbi.nlm.nih.gov/pubmed/27928513 http://dx.doi.org/10.1039/c6re00153j

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