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Thyroid dysfunction among type 2 diabetic female Egyptian subjects
PURPOSE: High prevalence of thyroid disorders is more common in type 1 diabetes compared to type 2 diabetes, due to associated autoimmunity. Hypothyroidism is the most common disorder. The objective was to assess the prevalence of thyroid dysfunction among type 2 diabetic Egyptian females and to fin...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove Medical Press
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5123662/ https://www.ncbi.nlm.nih.gov/pubmed/27920545 http://dx.doi.org/10.2147/TCRM.S112302 |
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author | Elebrashy, Ibrahim N El Meligi, Amr Rashed, Laila Salam, Randa F Youssef, Elham Fathy, Shaimaa A |
author_facet | Elebrashy, Ibrahim N El Meligi, Amr Rashed, Laila Salam, Randa F Youssef, Elham Fathy, Shaimaa A |
author_sort | Elebrashy, Ibrahim N |
collection | PubMed |
description | PURPOSE: High prevalence of thyroid disorders is more common in type 1 diabetes compared to type 2 diabetes, due to associated autoimmunity. Hypothyroidism is the most common disorder. The objective was to assess the prevalence of thyroid dysfunction among type 2 diabetic Egyptian females and to find the correlation between metabolic syndrome components and autoimmune thyroid dysfunction. MATERIALS AND METHODS: The study included 62 type 2 diabetic Egyptian females and 27 sex- and age-matched controls. All patients in the study were subjected to anthropometric measures, including HbA(1c), lipid profile, serum uric acid, thyroid-stimulating hormone (TSH), free triiodothyronine, free thyroxine, anti-thyroid peroxidase (TPO), antithyroglobulin (anti-Tg), and thyroid ultrasound. RESULTS: Hypothyroidism was found in 45.2% of patients (5.49±3.37 μIU/mL) versus 11.1% of controls (1.79±1.21 μIU/mL) (P<0.001). Anti-TPO was found in 75.8% (347.15±244.87 IU/mL) of patients versus 7.4% (32.89±33.26 IU/mL) of controls (P<0.001). Anti-Tg was found in 61.3% (508.03±369.16 IU/mL) of patients versus 0 (51.26±35.53 IU/mL) controls (P<0.001). A significant positive correlation was found between TSH and antithyroid antibodies (anti-Tg, anti-TPO; P=0.002 and P=0.043, respectively) and between TSH and thyroid-gland volume (P=0.002) in diabetic patients. No correlation was found between any components of metabolic syndrome and thyroid antibodies in diabetic patients. CONCLUSION: Autoimmune thyroid disease is more common in Egyptian women with type 2 diabetes than nondiabetic women, and thus points to a role of autoimmunity in the pathogenesis of type 2 diabetes. |
format | Online Article Text |
id | pubmed-5123662 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Dove Medical Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-51236622016-12-05 Thyroid dysfunction among type 2 diabetic female Egyptian subjects Elebrashy, Ibrahim N El Meligi, Amr Rashed, Laila Salam, Randa F Youssef, Elham Fathy, Shaimaa A Ther Clin Risk Manag Original Research PURPOSE: High prevalence of thyroid disorders is more common in type 1 diabetes compared to type 2 diabetes, due to associated autoimmunity. Hypothyroidism is the most common disorder. The objective was to assess the prevalence of thyroid dysfunction among type 2 diabetic Egyptian females and to find the correlation between metabolic syndrome components and autoimmune thyroid dysfunction. MATERIALS AND METHODS: The study included 62 type 2 diabetic Egyptian females and 27 sex- and age-matched controls. All patients in the study were subjected to anthropometric measures, including HbA(1c), lipid profile, serum uric acid, thyroid-stimulating hormone (TSH), free triiodothyronine, free thyroxine, anti-thyroid peroxidase (TPO), antithyroglobulin (anti-Tg), and thyroid ultrasound. RESULTS: Hypothyroidism was found in 45.2% of patients (5.49±3.37 μIU/mL) versus 11.1% of controls (1.79±1.21 μIU/mL) (P<0.001). Anti-TPO was found in 75.8% (347.15±244.87 IU/mL) of patients versus 7.4% (32.89±33.26 IU/mL) of controls (P<0.001). Anti-Tg was found in 61.3% (508.03±369.16 IU/mL) of patients versus 0 (51.26±35.53 IU/mL) controls (P<0.001). A significant positive correlation was found between TSH and antithyroid antibodies (anti-Tg, anti-TPO; P=0.002 and P=0.043, respectively) and between TSH and thyroid-gland volume (P=0.002) in diabetic patients. No correlation was found between any components of metabolic syndrome and thyroid antibodies in diabetic patients. CONCLUSION: Autoimmune thyroid disease is more common in Egyptian women with type 2 diabetes than nondiabetic women, and thus points to a role of autoimmunity in the pathogenesis of type 2 diabetes. Dove Medical Press 2016-11-21 /pmc/articles/PMC5123662/ /pubmed/27920545 http://dx.doi.org/10.2147/TCRM.S112302 Text en © 2016 Elebrashy et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. |
spellingShingle | Original Research Elebrashy, Ibrahim N El Meligi, Amr Rashed, Laila Salam, Randa F Youssef, Elham Fathy, Shaimaa A Thyroid dysfunction among type 2 diabetic female Egyptian subjects |
title | Thyroid dysfunction among type 2 diabetic female Egyptian subjects |
title_full | Thyroid dysfunction among type 2 diabetic female Egyptian subjects |
title_fullStr | Thyroid dysfunction among type 2 diabetic female Egyptian subjects |
title_full_unstemmed | Thyroid dysfunction among type 2 diabetic female Egyptian subjects |
title_short | Thyroid dysfunction among type 2 diabetic female Egyptian subjects |
title_sort | thyroid dysfunction among type 2 diabetic female egyptian subjects |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5123662/ https://www.ncbi.nlm.nih.gov/pubmed/27920545 http://dx.doi.org/10.2147/TCRM.S112302 |
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