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Pharmacokinetics and safety of DTS-108, a human oligopeptide bound to SN-38 with an esterase-sensitive cross-linker in patients with advanced malignancies: a Phase I study

BACKGROUND: DTS-108 is a hydrosoluble prodrug, where the SN-38 moiety is covalently linked to a 20-amino acid vector peptide by a specific esterase-sensitive cross-linker, releasing 7-ethyl-10-hydroxycampthotecin (SN-38) by esterase bond cleavage. METHODS: The pharmacokinetics of DTS-108, adverse ev...

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Detalles Bibliográficos
Autores principales:	Coriat, Romain, Faivre, Sandrine J, Mir, Olivier, Dreyer, Chantal, Ropert, Stanislas, Bouattour, Mohammed, Desjardins, Robert, Goldwasser, François, Raymond, Eric
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove Medical Press 2016
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5123727/ https://www.ncbi.nlm.nih.gov/pubmed/27920527 http://dx.doi.org/10.2147/IJN.S110274

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